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Age-related T1 mapping, fat fraction, diffusion and perfusion parameters of the lumbar vertebrae in healthy children under 3.0 T MRI.
Wang, L; Li, X; Li, Y; Zheng, M; Wang, C; Ye, Z.
Afiliación
  • Wang L; Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China; Department of Medical Imaging, Tianjin Children's Hospital
  • Li X; Department of Medical Imaging, Tianjin Children's Hospital (Children's Hospital of Tianjin University), Tianjin, China.
  • Li Y; Department of Medical Imaging, Tianjin Children's Hospital (Children's Hospital of Tianjin University), Tianjin, China.
  • Zheng M; Department of Medical Imaging, Tianjin Children's Hospital (Children's Hospital of Tianjin University), Tianjin, China.
  • Wang C; Department of Medical Imaging, Tianjin Children's Hospital (Children's Hospital of Tianjin University), Tianjin, China.
  • Ye Z; Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China. Electronic address: yezhaoxiang@163.com.
Clin Radiol ; 79(10): e1235-e1242, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39025718
ABSTRACT

AIM:

Compare the T1 mapping, fat fraction, diffusion and perfusion parameters of the lumbar vertebrae of different age groups to establish normal values for healthy children and observe the trends in these parameters with age. MATERIALS AND

METHODS:

A total of 146 healthy children (0-14 years) were included in this prospective study and underwent 3.0 T lumbar MRI examination. The study cohort was divided into five age groups (Group A âˆ¼ E) according to development milestones in children. T1 mapping, Dixon and IVIM (intravoxel incoherent motion)sequence images were used to measure the parameters of lumbar vertebrae 2-4.

RESULTS:

The normal values of each parameter were measured and compared across different age groups. The T1 value was negatively correlated with age (r=-0.619, p<0.001). The fat fraction (FF%) was positively correlated with age (r=0.635, p<0.001). There was a negative correlation between the D value and age (r=-0.406, p<0.001). The D∗ value was positively correlated with age (r=0.54, p<0.001). The f value was positively correlated with age (r=0.775, p<0.001). The inflexion points of the T1 value and FF% curves were at approximately 3 years old (36 months).The inflexion points of the IVIM-related parameter curves were approximately 5 years old (60 months).

CONCLUSION:

The age-dependent differences in the vertebral body parameters of this pediatric cohort suggest changes in the bone marrow composition and cellular structure of the vertebral body during physiological growth in children. The establishment of normal values of children's lumbar spine can facilitate the clinical study of diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Vértebras Lumbares Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: Clin Radiol Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Vértebras Lumbares Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: Clin Radiol Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido