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Baicalein suppresses Coxsackievirus B3 replication by inhibiting caspase-1 and viral protease 2A.
Dong, Yanyan; Shao, Enze; Li, Siwei; Wang, Ruiqi; Wang, Dan; Wang, Lixin; Yang, Hong; He, Yingxia; Luan, Tian; Chen, Yang; Wang, Yao; Lin, Lexun; Wang, Yan; Zhong, Zhaohua; Zhao, Wenran.
Afiliación
  • Dong Y; Department of Cell Biology, Harbin Medical University, Harbin 150081, China.
  • Shao E; Department of Cell Biology, Harbin Medical University, Harbin 150081, China.
  • Li S; Department of Cell Biology, Harbin Medical University, Harbin 150081, China.
  • Wang R; Department of Cell Biology, Harbin Medical University, Harbin 150081, China.
  • Wang D; Department of Cell Biology, Harbin Medical University, Harbin 150081, China.
  • Wang L; Department of Cell Biology, Harbin Medical University, Harbin 150081, China.
  • Yang H; Department of Cell Biology, Harbin Medical University, Harbin 150081, China.
  • He Y; Department of Cell Biology, Harbin Medical University, Harbin 150081, China.
  • Luan T; Department of Cell Biology, Harbin Medical University, Harbin 150081, China.
  • Chen Y; Department of Microbiology, Harbin Medical University, Harbin 150081, China.
  • Wang Y; Department of Cell Biology, Harbin Medical University, Harbin 150081, China.
  • Lin L; Department of Cell Biology, Harbin Medical University, Harbin 150081, China.
  • Wang Y; Department of Microbiology, Harbin Medical University, Harbin 150081, China.
  • Zhong Z; Department of Microbiology, Harbin Medical University, Harbin 150081, China. Electronic address: zhongzh@hrbmu.edu.cn.
  • Zhao W; Department of Cell Biology, Harbin Medical University, Harbin 150081, China. Electronic address: zhaowr@hrbmu.edu.cn.
Virol Sin ; 39(4): 685-693, 2024 Aug.
Article en En | MEDLINE | ID: mdl-39025463
ABSTRACT
Myocarditis is an inflammatory disease of the cardiac muscle and one of the primary causes of dilated cardiomyopathy. Group B coxsackievirus (CVB) is one of the leading causative pathogens of viral myocarditis, which primarily affects children and young adults. Due to the lack of vaccines, the development of antiviral medicines is crucial to controlling CVB infection and the progression of myocarditis. In this study, we investigated the antiviral effect of baicalein, a flavonoid extracted from Scutellaria baicaleinsis. Our results demonstrated that baicalein treatment significantly reduced cytopathic effect and increased cell viability in CVB3-infected cells. In addition, significant reductions in viral protein 3D, viral RNA, and viral particles were observed in CVB3-infected cells treated with baicalein. We found that baicalein exerted its inhibitory effect in the early stages of CVB3 infection. Baicalein also suppressed viral replication in the myocardium and effectively alleviated myocarditis induced by CVB3 infection. Our study revealed that baicalein exerts its antiviral effect by inhibiting the activity of caspase-1 and viral protease 2A. Taken together, our findings demonstrate that baicalein has antiviral activity against CVB3 infection and may serve as a potential therapeutic option for the myocarditis caused by enterovirus infection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Replicación Viral / Enterovirus Humano B / Caspasa 1 / Flavanonas / Miocarditis Límite: Animals / Humans / Male Idioma: En Revista: Virol Sin Asunto de la revista: VIROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Replicación Viral / Enterovirus Humano B / Caspasa 1 / Flavanonas / Miocarditis Límite: Animals / Humans / Male Idioma: En Revista: Virol Sin Asunto de la revista: VIROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos