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Placenta-derived mesenchymal stem cells promote diabetic wound healing via exosomal protein interaction networks.
Peng, Cheng; Xu, Hongbo; Zhuang, Quan; Liu, Jinya; Ding, Yinhe; Tang, Qiyu; Wang, Zheng; Yao, Kai.
Afiliación
  • Peng C; Department of Burns and Plastic Surgery, The Third Xiangya Hospital of Central South University, Changsha, China.
  • Xu H; Department of Vascular Surgery, The Third Xiangya Hospital of Central South University, Changsha, China.
  • Zhuang Q; Transplantation Center, The Third Xiangya Hospital of Central South University, Changsha, China.
  • Liu J; Department of Burns and Plastic Surgery, The Third Xiangya Hospital of Central South University, Changsha, China.
  • Ding Y; Department of Spine Surgery, The Xiangya Hospital of Central South University, Changsha, China.
  • Tang Q; Department of Burns and Plastic Surgery, The Third Xiangya Hospital of Central South University, Changsha, China.
  • Wang Z; Department of Vascular Surgery, The Third Xiangya Hospital of Central South University, Changsha, China.
  • Yao K; Department of Vascular Surgery, The Third Xiangya Hospital of Central South University, Changsha, China.
Wound Repair Regen ; 2024 Jul 18.
Article en En | MEDLINE | ID: mdl-39022990
ABSTRACT
There is a lack of effective treatment options for diabetic refractory wounds, which presents a critical clinical issue that needs to be addressed urgently. Our research has demonstrated that human placenta-derived mesenchymal stem cells (plaMSCs) facilitate the migration and proliferation of HaCat cells, thereby enhancing diabetic wound healing primarily via the exosomes derived from plaMSCs (plaMSCs-Ex). Using label-free proteomics, plaMSCs and their exosomes were analysed for proteome taxonomic content in order to explore the underlying effective components mechanism of plaMSCs-Ex in diabetic wound healing. Differentially expressed proteins enriched in plaMSCs-Ex were identified and underwent bioinformatics analysis including GO annotation, KEGG pathway enrichment, gene set enrichment analysis (GSEA) and protein-protein interaction analysis (PPI). Results showed that the proteins enriched in plaMSCs-Ex are significantly involved in extracellular matrix organisation, epithelium morphogenesis, cell growth, adhesion, proliferation and angiogenesis. PPI analysis filtered 2 wound healing-related clusters characterised by hub proteins such as POSTN, FN1, SPARC, TIMP1, SERPINE1, LRP1 and multiple collagens. In brief, the exosomal proteins derived from plaMSCs reveal diverse functions of regeneration and tissue remodelling based on proteomics analysis and potentially play a role in diabetic wound healing.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Wound Repair Regen Asunto de la revista: DERMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Wound Repair Regen Asunto de la revista: DERMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos