Histone demethylase PHF8 promotes prostate cancer metastasis via the E2F1-SNAI1 axis.
J Pathol
; 264(1): 68-79, 2024 Sep.
Article
en En
| MEDLINE
| ID: mdl-39022843
ABSTRACT
Metastasis is the primary culprit behind cancer-related fatalities in multiple cancer types, including prostate cancer. Despite great advances, the precise mechanisms underlying prostate cancer metastasis are far from complete. By using a transgenic mouse prostate cancer model (TRAMP) with and without Phf8 knockout, we have identified a crucial role of PHF8 in prostate cancer metastasis. By complexing with E2F1, PHF8 transcriptionally upregulates SNAI1 in a demethylation-dependent manner. The upregulated SNAI1 subsequently enhances epithelial-to-mesenchymal transition (EMT) and metastasis. Given the role of the abnormally activated PHF8/E2F1-SNAI1 axis in prostate cancer metastasis and poor prognosis, the levels of PHF8 or the activity of this axis could serve as biomarkers for prostate cancer metastasis. Moreover, targeting this axis could become a potential therapeutic strategy for prostate cancer treatment. © 2024 The Pathological Society of Great Britain and Ireland.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
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Factores de Transcripción
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Factor de Transcripción E2F1
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Histona Demetilasas
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Transición Epitelial-Mesenquimal
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Factores de Transcripción de la Familia Snail
Límite:
Animals
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Humans
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Male
Idioma:
En
Revista:
J Pathol
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Reino Unido