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Human NK cells and cancer.
Cantoni, Claudia; Falco, Michela; Vitale, Massimo; Pietra, Gabriella; Munari, Enrico; Pende, Daniela; Mingari, Maria Cristina; Sivori, Simona; Moretta, Lorenzo.
Afiliación
  • Cantoni C; Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.
  • Falco M; Laboratory of Clinical and Experimental Immunology, Integrated Department of Services and Laboratories, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
  • Vitale M; Laboratory of Clinical and Experimental Immunology, Integrated Department of Services and Laboratories, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
  • Pietra G; UO Pathology and Experimental Immunology, IRCCS Ospedale Policlinico, San Martino, Genova, Italy.
  • Munari E; Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.
  • Pende D; UO Pathology and Experimental Immunology, IRCCS Ospedale Policlinico, San Martino, Genova, Italy.
  • Mingari MC; Pathology Unit, Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, Italy.
  • Sivori S; UO Pathology and Experimental Immunology, IRCCS Ospedale Policlinico, San Martino, Genova, Italy.
  • Moretta L; Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.
Oncoimmunology ; 13(1): 2378520, 2024.
Article en En | MEDLINE | ID: mdl-39022338
ABSTRACT
The long story of NK cells started about 50 y ago with the first demonstration of a natural cytotoxic activity within an undefined subset of circulating leukocytes, has involved an ever-growing number of researchers, fascinated by the apparently easy-to-reach aim of getting a "universal anti-tumor immune tool". In fact, in spite of the impressive progress obtained in the first decades, these cells proved far more complex than expected and, paradoxically, the accumulating findings have continuously moved forward the attainment of a complete control of their function for immunotherapy. The refined studies of these latter years have indicated that NK cells can epigenetically calibrate their functional potential, in response to specific environmental contexts, giving rise to extraordinarily variegated subpopulations, comprehensive of memory-like cells, tissue-resident cells, or cells in various differentiation stages, or distinct functional states. In addition, NK cells can adapt their activity in response to a complex body of signals, spanning from the interaction with either suppressive or stimulating cells (myeloid-derived suppressor cells or dendritic cells, respectively) to the engagement of various receptors (specific for immune checkpoints, cytokines, tumor/viral ligands, or mediating antibody-dependent cell-mediated cytotoxicity). According to this picture, the idea of an easy and generalized exploitation of NK cells is changing, and the way is opening toward new carefully designed, combined and personalized therapeutic strategies, also based on the use of genetically modified NK cells and stimuli capable of strengthening and redirecting their effector functions against cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Asesinas Naturales / Neoplasias Límite: Animals / Humans Idioma: En Revista: Oncoimmunology Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Asesinas Naturales / Neoplasias Límite: Animals / Humans Idioma: En Revista: Oncoimmunology Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos