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PDCD2 as a prognostic biomarker in glioma correlates with malignant phenotype.
Dai, Fengsheng; Yuan, Yixiao; Hao, Jiaqi; Cheng, Xing; Zhou, Xiangyi; Zhou, Li; Tian, Rui; Zhao, Yi; Xiang, Tingxiu.
Afiliación
  • Dai F; Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
  • Yuan Y; Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing 400030, China.
  • Hao J; Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
  • Cheng X; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
  • Zhou X; Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
  • Zhou L; Department of Neuro-Oncology, Chongqing University Cancer Hospital, Chongqing 400030, China.
  • Tian R; Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
  • Zhao Y; Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing 400030, China.
  • Xiang T; Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing 400030, China.
Genes Dis ; 11(5): 101106, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39022129
ABSTRACT
Programmed cell death 2 (PDCD2) is related to cancer progression and chemotherapy sensitivity. The role of PDCD2 in solid cancers (excluding hematopoietic malignancies) and their diagnosis and prognosis remains unclear. The TCGA, CGGA, GEPIA, cBioPortal, and GTEx databases were analyzed for expression, prognostic value, and genetic modifications of PDCD2 in cancer patients. Functional enrichment analysis, CCK8, colony formation assay, transwell assay, and xenograft tumor model were undertaken to study the PDCD2's biological function in glioma (GBMLGG). The PDCD2 gene was associated with solid cancer progression. In the functional enrichment analysis results, PDCD2 was shown to participate in several important GBMLGG biological processes. GBMLGG cells may be inhibited in their proliferation, migration, invasion, and xenograft tumor growth by knocking down PDCD2. Our research can provide new insights into solid cancer prognostic biomarkers of PDCD2.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Genes Dis Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Genes Dis Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos