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A clinical study based on bidirectional Mendelian randomization: Correlation between generalized anxiety disorder and weight-bearing joints osteoarthritis.
Ma, Xiao; Zhang, Han; Li, Guangyu; Ma, Jingjing; Cheng, Wendan; Wang, Tianrui; Zhang, Yingze.
Afiliación
  • Ma X; Department of Orthopaedics, The Affiliated Hospital of Qingdao University, Qingdao, China.
  • Zhang H; Qingdao Medical College, Qingdao University, Qingdao, China.
  • Li G; Department of Orthopaedics, The Affiliated Hospital of Qingdao University, Qingdao, China.
  • Ma J; Qingdao Medical College, Qingdao University, Qingdao, China.
  • Cheng W; Department of Orthopedics, Xinjiang Medical University, Urumchi, China.
  • Wang T; Radiation Oncology Center, The Fifth Medical Center of PLA General Hospital, Beijing, China.
  • Zhang Y; Department of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Heliyon ; 10(12): e32988, 2024 Jun 30.
Article en En | MEDLINE | ID: mdl-39021945
ABSTRACT

Objectives:

Bidirectional Mendelian randomization (MR) combined with clinical case analysis was used to elucidate the relationship between generalized anxiety disorder (GAD) caused by mental overload and the risk of weight-bearing joint (hip/knee) osteoarthritis (OA).

Methods:

We performed MR analyses using publicly released genome-wide association study summary statistics to measure the causal effects between mental overload and weight-bearing joint OA risk. The primary MR analysis utilized the inverse-variance weighted (IVW) method, complemented by additional methods, including simple mode, weighted mode, MR-Egger regression, and weighted median. The leave-one-out method was used for sensitivity analysis. Concurrently, data from patients with OA (Kellgren-Lawrence grades III-IV) who needed total knee/hip arthroplasty were collected. Patient assessments were conducted utilizing the Western Ontario and McMaster Universities arthritis index, Penn State worry questionnaire, and visual analogue scale.

Results:

Genetically predisposed GAD did not correlate with the risk of weight-bearing joint OA (IVW odds ratio [OR] = 0.840, 95 % confidence interval = 0.128, 5.50, P = 0.855). In reverse MR analyses, we detected no causal effect of weight-bearing OA on GAD (IVW OR = 1.00, 95 % CI = 0.985, 1.03, P = 0.687). In the clinical case evaluation, weight overload joint OA and GAD were highly correlated.

Conclusion:

MR analysis indicated no bidirectional causal effect of GAD caused by mental overload on weight-bearing joint (hip or knee) OA. Clinical studies support the finding that GAD is highly correlated with weight-bearing joint OA. However, whether there is a causal relationship between GAD caused by mental overload and weight-overloading joint OA requires further investigation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido