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Biological alterations associated with the orthodontic treatment with conventional appliances and aligners: A systematic review of clinical and preclinical evidence.
Gonçalves, Aline; Mathelié-Guinlet, Quitterie; Ramires, Fátima; Monteiro, Francisca; Carvalho, Óscar; Silva, Filipe S; Resende, Albina D; Pinho, Teresa.
Afiliación
  • Gonçalves A; UNIPRO - Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS), CESPU, 4585-116, Gandra, Portugal.
  • Mathelié-Guinlet Q; Center for MicroElectroMechanical Systems (CMEMS), University of Minho, Campus Azurém, 4800-058, Guimarães, Portugal.
  • Ramires F; UNIPRO - Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS), CESPU, 4585-116, Gandra, Portugal.
  • Monteiro F; UNIPRO - Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS), CESPU, 4585-116, Gandra, Portugal.
  • Carvalho Ó; Center for MicroElectroMechanical Systems (CMEMS), University of Minho, Campus Azurém, 4800-058, Guimarães, Portugal.
  • Silva FS; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.
  • Resende AD; Center for MicroElectroMechanical Systems (CMEMS), University of Minho, Campus Azurém, 4800-058, Guimarães, Portugal.
  • Pinho T; LABBELS - Associate Laboratory, Braga, Guimarães, Portugal.
Heliyon ; 10(12): e32873, 2024 Jun 30.
Article en En | MEDLINE | ID: mdl-39021939
ABSTRACT
Background&

objectives:

Mechanical forces applied during an orthodontic tooth movement (OTM) propel several biochemical and molecular responses in the periodontal ligament and alveolar bone. Here, we compile the existing clinical and preclinical evidence on these biological changes, aiming to provide a comprehensive discussion on the influence of the mechanical parameters of the OTM in the biological profile of the periodontium. Material and

methods:

This systematic integrative review was conducted according to PICOS strategy and PRISMA guidelines. A bibliographic search was performed in three electronic databases (PubMed, Scopus, and Web of Science) to find research articles published until 2023 and written in English. This search resulted in a total of 2279 publications, which were independently assessed by two evaluators using appropriate tools.

Results:

Forty-six studies were selected for this review. These revealed that compression, and stretching of the periodontal ligament fibers and cells are observed in the initial phase of the OTM. Specifically, on the tension side, high levels of IL-1ß, OPG, and TIMPs are identified. On the compression side, an increase of RANKL, RANK, and MMPs levels predominate.

Conclusion:

This paper describes the release profile of common biomarkers according to the orthodontic protocol, suggesting the most appropriate parameters to keep the teeth and their supporting structures healthy. Overall, this manuscript provides a better understanding of the OTM-associated biological phenomena, also highlighting the importance of early evaluation of oral health, and thus it contributes as a fundamental basis for the development of more effective and safe orthodontic treatments with conventional appliances and aligners.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Reino Unido