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Prognostic heterogeneity of Ki67 in non-small cell lung cancer: A comprehensive reappraisal on immunohistochemistry and transcriptional data.
Yang, Yujing; Shao, Xinye; Li, Zhi; Zhang, Lingyun; Yang, Bowen; Jin, Bo; Hu, Xuejun; Qu, Xiujuan; Che, Xiaofang; Liu, Yunpeng.
Afiliación
  • Yang Y; Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, China.
  • Shao X; Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, The First Hospital of China Medical University, Shenyang, China.
  • Li Z; Clinical Cancer Research Center of Shenyang, The First Hospital of China Medical University, Shenyang, China.
  • Zhang L; Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Yang B; Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, China.
  • Jin B; Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, The First Hospital of China Medical University, Shenyang, China.
  • Hu X; Clinical Cancer Research Center of Shenyang, The First Hospital of China Medical University, Shenyang, China.
  • Qu X; Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, China.
  • Che X; Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, China.
  • Liu Y; Clinical Cancer Research Center of Shenyang, The First Hospital of China Medical University, Shenyang, China.
J Cell Mol Med ; 28(14): e18521, 2024 Jul.
Article en En | MEDLINE | ID: mdl-39021279
ABSTRACT
In the present study, the debatable prognostic value of Ki67 in patients with non-small cell lung cancer (NSCLC) was attributed to the heterogeneity between lung adenocarcinoma (LUAD) and lung squamous carcinoma (LUSC). Based on meta-analyses of 29 studies, a retrospective immunohistochemical cohort of 1479 patients from our center, eight transcriptional datasets and a single-cell datasets with 40 patients, we found that high Ki67 expression suggests a poor outcome in LUAD, but conversely, low Ki67 expression indicates worse prognosis in LUSC. Furthermore, low proliferation in LUSC is associated with higher metastatic capacity, which is related to the stronger epithelial-mesenchymal transition potential, immunosuppressive microenvironment and angiogenesis. Finally, nomogram model incorporating clinical risk factors and Ki67 expression outperformed the basic clinical model for the accurate prognostic prediction of LUSC. With the largest prognostic assessment of Ki67 from protein to mRNA level, our study highlights that Ki67 also has an important prognostic value in NSCLC, but separate evaluation of LUAD and LUSC is necessary to provide more valuable information for clinical decision-making in NSCLC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunohistoquímica / Carcinoma de Pulmón de Células no Pequeñas / Antígeno Ki-67 / Neoplasias Pulmonares Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Cell Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunohistoquímica / Carcinoma de Pulmón de Células no Pequeñas / Antígeno Ki-67 / Neoplasias Pulmonares Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Cell Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido