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Stimulating Novel and Bioactive Metabolite Production by Cocultivation of Two Fungi─Aspergillus oryzae and Epicoccum dendrobii.
Shen, Xiangrui; Lei, Chengzhi; Zhang, Anxin; Wang, Long; Chen, Denghui; Qi, Landa; Hu, Yiliang; Chen, Guocan; Ran, Huomiao; Yin, Wen-Bing.
Afiliación
  • Shen X; School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, PR China.
  • Lei C; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China.
  • Zhang A; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China.
  • Wang L; Medical School, University of Chinese Academy of Sciences, Beijing 100049, PR China.
  • Chen D; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China.
  • Qi L; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China.
  • Hu Y; Henan Academy of Science Institute of Biology, Zhengzhou 450008, PR China.
  • Chen G; Henan Academy of Science Institute of Biology, Zhengzhou 450008, PR China.
  • Ran H; Henan Academy of Science Institute of Biology, Zhengzhou 450008, PR China.
  • Yin WB; Henan Academy of Science Institute of Biology, Zhengzhou 450008, PR China.
J Agric Food Chem ; 72(30): 16825-16834, 2024 Jul 31.
Article en En | MEDLINE | ID: mdl-39020512
ABSTRACT
Fungi produce various bioactive secondary metabolites (SMs) as protective and weaponized tools to enhance survival in shared ecological niches. By mimicking a competitive ecosystem, cocultivation has been proven to be particularly successful in stimulating SM discovery. Here, we reported the identification of four novel metabolites, epiclactones A and B, epioxochromane and aoergostane, from the coculture of two biotechnologically important strains, Aspergillus oryzae and Epicoccum dendrobii. Transcriptome and metabolome analyses revealed widespread silent gene activation during fungal-fungal interaction. The majority of differentially expressed gene clusters were summarized for both strains. Based on these highly activated biosynthetic pathways, we suggested that a bidirectional chemical defense occurred under cocultivation. E. dendrobii enhanced the production of the spore inhibitor, fumigermin. Moreover, A. oryzae highly accumulated the antifungal agent kojic acid with a yield of up to 1.10 g/L. This study provides an excellent example for the discovery of hidden natural products by cocultivation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ascomicetos / Aspergillus oryzae / Técnicas de Cocultivo Idioma: En Revista: J Agric Food Chem Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ascomicetos / Aspergillus oryzae / Técnicas de Cocultivo Idioma: En Revista: J Agric Food Chem Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos