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Tumefactive cerebral amyloid angiopathy - related inflammation.
Stardeli, Thomai; Kitmeridou, Sofia; Ioannidis, Panagiotis.
Afiliación
  • Stardeli T; Department of Neurology, AHEPA University Hospital, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54636, Thessaloniki, Greece. starth96@yahoo.com.
  • Kitmeridou S; Neurology Department, Department of Medicine, Faculty of Health Sciences, Democritus University of Thrace, 68100, Alexandroupolis, Greece.
  • Ioannidis P; Department of Neurology, AHEPA University Hospital, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54636, Thessaloniki, Greece.
Neurol Sci ; 2024 Jul 17.
Article en En | MEDLINE | ID: mdl-39017757
ABSTRACT

INTRODUCTION:

Cerebral amyloid angiopathy-related inflammation (CAA-ri) derives from inflammatory response to ß-amyloid (Aß) protein deposition within the cerebral blood vessel walls. We report a case that accentuates those clinical and imaging features that can contribute to raise suspicion for the condition and lead to early treatment initiation. CASE PRESENTATION A 72-year-old man was referred with one-month history of cognitive decline along with behavioral alterations. Brain MRI showed fluid attenuated inversion recovery (FLAIR) asymmetrical multifocal white matter hyperintensities (WMHs) along with multiple cerebral microbleeds (CMBs) and cortical superficial siderosis (cSS) on T2*-weighted gradient-recalled echo (T2*-GRE) images. Metabolic, infectious, and neoplastic causes were excluded, and subsequently corticosteroids were administered to the patient resulting in clinical recovery. Imaging on follow-up disclosed remission of WMHs, while CMBs load increased significantly.

DISCUSSION:

Clinical neurologists' acquaintance with the clinical and imaging features of CAA-ri allows prompt diagnosis and medication initiation, that is essential for a conceivably treatable condition.
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Neurol Sci Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Italia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Neurol Sci Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Italia