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Exercise training and spexin ameliorate thyroid changes in obese type 2 diabetic rats: the possible interlaying mechanisms.
Rizk, Fatma H; Barhoma, Ramez A E; El-Saka, Mervat H; Ibrahim, Hoda A; El-Gohary, Rehab M; Ismail, Radwa; Motawea, Shaimaa M; Salem, Ola; Hegab, Islam Ibrahim.
Afiliación
  • Rizk FH; Department of Physiology, Faculty of Medicine, Tanta University, Tanta, Egypt.
  • Barhoma RAE; Department of Physiology, Faculty of Medicine, Tanta University, Tanta, Egypt.
  • El-Saka MH; Department of Restorative Dentistry and Basic Medical Sciences, Faculty of Dentistry, University of Petra, Amman, Jordan.
  • Ibrahim HA; Department of Physiology, Faculty of Medicine, Tanta University, Tanta, Egypt.
  • El-Gohary RM; Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Tanta, Egypt.
  • Ismail R; Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Tanta, Egypt.
  • Motawea SM; Department of Anatomy and Embryology, Faculty of Medicine, Tanta University, Tanta, Egypt.
  • Salem O; Department of Anatomy and Embryology, Faculty of Medicine, Tanta University, Tanta, Egypt.
  • Hegab II; Department of Pharmacology, Faculty of Medicine, Tanta University, Tanta, Egypt.
Am J Physiol Endocrinol Metab ; 327(3): E313-E327, 2024 Sep 01.
Article en En | MEDLINE | ID: mdl-39017682
ABSTRACT
Thyroid dysfunction and diabetes mellitus are prevalent endocrine disorders that often coexist and influence each other. The role of spexin (SPX) in diabetes and obesity is well documented, but its connection to thyroid function is less understood. This study investigates the influence of exercise (EX) and SPX on thyroid hypofunction in obese type 2 diabetic rats. Rats were divided into normal control, obese diabetic sedentary, obese diabetic EX, and obese diabetic SPX groups, with subdivisions for M871 and HT-2157 treatment in the latter two groups. High-fat diet together with streptozotocin (STZ) injection induced obesity and diabetes. The EX group underwent swimming, and the SPX group received SPX injections for 8 wk. Results showed significant improvements in thyroid function and metabolic, oxidative, and inflammatory states with EX and SPX treatment. The study also explored the involvement of galanin receptor isoforms (GALR)2/3 in SPX effects on thyroid function. Blocking GALR2/3 receptors partially attenuated the beneficial effects, indicating their interaction. These findings underscore the importance of EX and SPX in modulating thyroid function in obesity and diabetes. Comprehending this interplay could enable the development of new treatment approaches for thyroid disorders associated with obese type 2 diabetes. Additional research is necessary to clarify the exact mechanisms connecting SPX, EX activity, and thyroid function.NEW & NOTEWORTHY This study proves, for the first time, the beneficial effects of SPX on thyroid dysfunction in obese diabetic rats and suggests that SPX mediates the EX effect on thyroid gland and exerts its effect mainly via GALR2.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Condicionamiento Físico Animal / Glándula Tiroides / Hormonas Peptídicas / Diabetes Mellitus Experimental / Diabetes Mellitus Tipo 2 / Dieta Alta en Grasa / Obesidad Límite: Animals Idioma: En Revista: Am J Physiol Endocrinol Metab Asunto de la revista: ENDOCRINOLOGIA / FISIOLOGIA / METABOLISMO Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Condicionamiento Físico Animal / Glándula Tiroides / Hormonas Peptídicas / Diabetes Mellitus Experimental / Diabetes Mellitus Tipo 2 / Dieta Alta en Grasa / Obesidad Límite: Animals Idioma: En Revista: Am J Physiol Endocrinol Metab Asunto de la revista: ENDOCRINOLOGIA / FISIOLOGIA / METABOLISMO Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Estados Unidos