UBE2D1 promotes glioblastoma proliferation by modulating p21 ubiquitination.

Wang, Yongfeng; Ma, Qianquan; Li, Haoyu; Huang, Wei; You, Jia; Liu, Dian

Wang, Yongfeng; Ma, Qianquan; Li, Haoyu; Huang, Wei; You, Jia; Liu, Dian.

Afiliación

Wang Y; Department of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Key Clinical Laboratory of Henan Province, Zhengzhou, China.
Ma Q; Department of Neurosurgery, Peking University Third Hospital, Peking University, Beijing, China.
Li H; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Huang W; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
You J; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Liu D; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.

Mol Carcinog ; 63(10): 1967-1979, 2024 Oct.

Article en En | MEDLINE | ID: mdl-39016669

ABSTRACT

ABSTRACT

Glioblastoma (GBM) cells exhibit aberrant proliferative abilities and resistance to conventional therapies. However, the mechanisms underlying these malignant phenotypes are poorly understood. In this study, we identified ubiquitin-conjugating enzyme E2D1 (UBE2D1) as a crucial stimulator of GBM development. It is highly expressed in GBM and closely associated with poor prognosis in patients with GBM. UBE2D1 knockdown inhibits GBM cell growth and leads to G1 cell cycle arrest. Mechanistically, UBCH5A binds to p21 at the protein level and induces the ubiquitination and degradation of p21. This negative regulation is mediated by STUB1. Our findings are the first to identify UBE2D1 as a key driver of GBM growth and provide a potential target for improving prognosis and therapy.

Asunto(s)

Neoplasias Encefálicas; Proliferación Celular; Inhibidor p21 de las Quinasas Dependientes de la Ciclina; Glioblastoma; Enzimas Ubiquitina-Conjugadoras; Ubiquitinación; Humanos; Glioblastoma/patología; Glioblastoma/metabolismo; Glioblastoma/genética; Enzimas Ubiquitina-Conjugadoras/metabolismo; Enzimas Ubiquitina-Conjugadoras/genética; Inhibidor p21 de las Quinasas Dependientes de la Ciclina/metabolismo; Inhibidor p21 de las Quinasas Dependientes de la Ciclina/genética; Línea Celular Tumoral; Neoplasias Encefálicas/patología; Neoplasias Encefálicas/metabolismo; Neoplasias Encefálicas/genética; Regulación Neoplásica de la Expresión Génica; Ubiquitina-Proteína Ligasas/metabolismo; Ubiquitina-Proteína Ligasas/genética; Pronóstico; Animales; Ratones; Ratones Desnudos; Masculino; Femenino

Palabras clave

UBE2D1; glioblastoma; p21; ubiquitination

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Glioblastoma / Enzimas Ubiquitina-Conjugadoras / Proliferación Celular / Inhibidor p21 de las Quinasas Dependientes de la Ciclina / Ubiquitinación Límite: Animals / Female / Humans / Male Idioma: En Revista: Mol Carcinog Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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