New characteristics of polycystic ovary syndrome phenotypes according to gas chromatography-mass spectrometry-based study of urinary steroid metabolome.

Yarmolinskaya, Maria I; Glavnova, Olga B; Vorokhobina, Natalia V; Velikanova, Ludmila I; Malevanaya, Ekaterina V

Yarmolinskaya, Maria I; Glavnova, Olga B; Vorokhobina, Natalia V; Velikanova, Ludmila I; Malevanaya, Ekaterina V.

Afiliación

Yarmolinskaya MI; Department of Gynecology and Endocrinology, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint-Petersburg State University, St. Petersburg, Russia - m.yarmolinskaya@gmail.com.
Glavnova OB; Department of Gynecology and Endocrinology, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint-Petersburg State University, St. Petersburg, Russia.
Vorokhobina NV; V.G. Baranov Department of Endocrinology, Science and Research Laboratory of Chromatography, North-Western State Medical University Named After I.I. Mechnikov, St. Petersburg, Russia.
Velikanova LI; V.G. Baranov Department of Endocrinology, Science and Research Laboratory of Chromatography, North-Western State Medical University Named After I.I. Mechnikov, St. Petersburg, Russia.
Malevanaya EV; V.G. Baranov Department of Endocrinology, Science and Research Laboratory of Chromatography, North-Western State Medical University Named After I.I. Mechnikov, St. Petersburg, Russia.

Minerva Obstet Gynecol ; 2024 Jul 17.

Article en En | MEDLINE | ID: mdl-39016550

ABSTRACT

ABSTRACT

BACKGROUND:

The most common cause of hyperandrogenism in women is polycystic ovary syndrome (PCOS), the prevalence of which among women of reproductive age ranges from 8.0 to 21%. The clinical manifestations of PCOS are diverse, and the degree of metabolic and hormonal disorders depends on the PCOS phenotype. The non-classic congenital adrenal hyperplasia (NCCAH) ranks second in the structure of diseases associated with hyperandrogenism. PCOS and NCCAH have a similar clinical picture and laboratory parameters, which requires differential diagnosis.

METHODS:

Urinary steroid profiles were studied by gas chromatography-mass spectrometry.

RESULTS:

We revealed differences in glucocorticoid and androgen metabolism in women with different PCOS phenotypes, which is reflected in the clinical manifestation of the disease. It was evaluated the activity of enzymes involved in the metabolism of steroid hormones. In patients with NCCAH, it was found that polycystic ovarian changes are secondary and develop due to the presence of prolonged adrenal hyperandrogenism.

CONCLUSIONS:

The results obtained are important for understanding the mechanisms of disorders in various variants of hyperandrogenism and determining further tactics for managing patients.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Minerva Obstet Gynecol Año: 2024 Tipo del documento: Article Pais de publicación: Italia

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