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Dysfunctional mitochondria elicit bioenergetic decline in the aged heart.
Mone, Pasquale; Agyapong, Esther Densu; Morciano, Giampaolo; Jankauskas, Stanislovas S; De Luca, Antonio; Varzideh, Fahimeh; Pinton, Paolo; Santulli, Gaetano.
Afiliación
  • Mone P; Department of Medicine (Division of Cardiology), Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA.
  • Agyapong ED; Department of Medicine and Health Sciences, University of Molise, Campobasso 86100, Italy.
  • Morciano G; Department of Medicine (Division of Cardiology), Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA.
  • Jankauskas SS; Department of Medical Sciences, University of Ferrara, Ferrara 44121, Italy.
  • De Luca A; Department of Medical Sciences, University of Ferrara, Ferrara 44121, Italy.
  • Varzideh F; Maria Cecilia Hospital, GVM Care & Research, Cotignola 48033, Italy.
  • Pinton P; Department of Medicine (Division of Cardiology), Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA.
  • Santulli G; Department of Mental and Physical Health and Preventive Medicine, Vanvitelli University, Naples 80100, Italy.
J Cardiovasc Aging ; 4(2)2024 Apr.
Article en En | MEDLINE | ID: mdl-39015481
ABSTRACT
Aging represents a complex biological progression affecting the entire body, marked by a gradual decline in tissue function, rendering organs more susceptible to stress and diseases. The human heart holds significant importance in this context, as its aging process poses life-threatening risks. It entails macroscopic morphological shifts and biochemical changes that collectively contribute to diminished cardiac function. Among the numerous pivotal factors in aging, mitochondria play a critical role, intersecting with various molecular pathways and housing several aging-related agents. In this comprehensive review, we provide an updated overview of the functional role of mitochondria in cardiac aging.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Cardiovasc Aging Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Cardiovasc Aging Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos