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Proteomic analysis of serum in a population-based cohort did not reveal a biomarker for Modic changes.
Schulze, Friederike; Määttä, Juhani; Grad, Sybille; Heggli, Irina; Brunner, Florian; Farshad, Mazda; Distler, Oliver; Karppinen, Jaro; Lotz, Jeffrey; Dudli, Stefan.
Afiliación
  • Schulze F; Center of Experimental Rheumatology, Department of Rheumatology University Hospital Zurich, University of Zurich Zurich Switzerland.
  • Määttä J; Department of Physical Medicine and Rheumatology Balgrist University Hospital, Balgrist Campus, University of Zurich Zurich Switzerland.
  • Grad S; Research Unit of Health Sciences and Technology University of Oulu Oulu Finland.
  • Heggli I; AO Research Institute Davos Davos Switzerland.
  • Brunner F; Center of Experimental Rheumatology, Department of Rheumatology University Hospital Zurich, University of Zurich Zurich Switzerland.
  • Farshad M; Department of Physical Medicine and Rheumatology Balgrist University Hospital, Balgrist Campus, University of Zurich Zurich Switzerland.
  • Distler O; Department of Orthopedics Balgrist University Hospital Zurich Switzerland.
  • Karppinen J; Center of Experimental Rheumatology, Department of Rheumatology University Hospital Zurich, University of Zurich Zurich Switzerland.
  • Lotz J; Research Unit of Health Sciences and Technology University of Oulu Oulu Finland.
  • Dudli S; Rehabilitation Services of South Karelia Social and Health Care District Lappeenranta Finland.
JOR Spine ; 7(3): e1337, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39015135
ABSTRACT

Introduction:

Modic changes (MC) are bone marrow lesions of vertebral bones, which can be detected with magnetic resonance imaging (MRI) adjacent to degenerated intervertebral discs. Defined by their appearance on T1 and T2 weighted images, there are three interconvertible types MC1, MC2, and MC3. The inter-observer variability of the MRI diagnosis is high, therefore a diagnostic serum biomarker complementing the MRI to facilitate diagnosis and follow-up would be of great value.

Methods:

We used a highly sensitive and reproducible proteomics

approach:

DIA/SWATH-MS to find serum biomarkers in a subset of the Northern Finland Birth Cohort 1966. Separately, we measured a panel of factors involved in inflammation and angiogenesis to confirm some potential biomarkers published before with an ELISA-based method called V-Plex.

Results:

We found neither an association between the serum concentrations of the proteins detected with DIA/SWATH-MS with the presence of MC, nor a correlation with the size of the MC lesions. We did not find any association between the factors measured with the V-Plex and the presence of MC or their size.

Conclusion:

Altogether, our study suggests that a robust and generally usable biomarker to facilitate the diagnosis of MC cannot readily be found in serum.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: JOR Spine Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: JOR Spine Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos