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Estimating cure and risk of death from other causes of cancer patients: EUROCARE-6 data on head & neck, colorectal, and breast cancers.
Botta, Laura; Capocaccia, Riccardo; Bernasconi, Alice; Rossi, Silvia; Galceran, Jaume; Maso, Luigino Dal; Lepage, Come; Molinié, Florence; Bouvier, Anne-Marie; Marcos-Gragera, Rafael; Vener, Claudia; Guevara, Marcela; Murray, Deirdre; Ragusa, Rosalia; Gatta, Gemma; Jooste, Valerie.
Afiliación
  • Botta L; Evaluative Epidemiology Unit, Department of Epidemiology and Data Science, Fondazione IRCCS Istituto nazionale dei Tumori, Milan, Italy; Digestive Cancer Registry of Burgundy, Dijon University Hospital, Dijon, France; INSERM CTM UMR 1231 EPICAD, University of Burgundy, Dijon, France. Electronic addr
  • Capocaccia R; Editorial Board, Epidemiologia e Prevenzione, Milan, Italy. Electronic address: capocaccia.riccardo@gmail.com.
  • Bernasconi A; Evaluative Epidemiology Unit, Department of Epidemiology and Data Science, Fondazione IRCCS Istituto nazionale dei Tumori, Milan, Italy. Electronic address: alice.bernasconi@istitutotumori.mi.it.
  • Rossi S; Istituto Superiore di Sanità, Department of Oncology and Molecular Medicine, Rome, Italy. Electronic address: silvia.rossi@iss.it.
  • Galceran J; Tarragona Cancer Registry, Cancer Epidemiology and Prevention Cancer Service, Hospital Universitari Sant Joan de Reus, Reus, Spain; Pere Virgili Health Research Institute, Reus, Spain. Electronic address: jaume.galceran@salutsantjoan.cat.
  • Maso LD; Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy. Electronic address: dalmaso@cro.it.
  • Lepage C; INSERM CTM UMR 1231 EPICAD, University of Burgundy, Dijon, France; Digestive oncology department, Dijon University Hospital, Dijon, France. Electronic address: come.lepage@u-bourgogne.fr.
  • Molinié F; FRANCIM Network, Toulouse F-31073, France; Loire-Atlantique/Vendée Cancer Registry, Nantes, France; UMR 1295, Université Toulouse III, Inserm, Equipe EQUITY, Equipe constitutive du CERPOP, Toulouse, France. Electronic address: florence.molinie@chu-nantes.fr.
  • Bouvier AM; Digestive Cancer Registry of Burgundy, Dijon University Hospital, Dijon, France; INSERM CTM UMR 1231 EPICAD, University of Burgundy, Dijon, France; FRANCIM Network, Toulouse F-31073, France. Electronic address: anne-marie.bouvier@u-bourgogne.fr.
  • Marcos-Gragera R; Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology, Girona Biomedical Research Institute (IdiBGi), Universitat de Girona, Girona, Spain; Centro de Investigación Biomédica en Red de Epidemio
  • Vener C; Epidemiology and Prevention Unit, Department of Epidemiology and Data Science, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; Analytical Epidemiology and Health Impact Unit, Department of Epidemiology and Data Science, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Elec
  • Guevara M; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain. Electronic address: mp.guevara.eslava@navarra.es.
  • Murray D; National Cancer Registry Ireland, Cork, Ireland; School of Public Health, University College Cork, Ireland. Electronic address: d.murray@ncri.ie.
  • Ragusa R; Catania-Messina-Enna CR, Azienda Ospedaliero Universitaria Policlinico, Catania, Italy. Electronic address: ragusar@unict.it.
  • Gatta G; Evaluative Epidemiology Unit, Department of Epidemiology and Data Science, Fondazione IRCCS Istituto nazionale dei Tumori, Milan, Italy. Electronic address: gemma.gatta@istitutotumori.mi.it.
  • Jooste V; Digestive Cancer Registry of Burgundy, Dijon University Hospital, Dijon, France; INSERM CTM UMR 1231 EPICAD, University of Burgundy, Dijon, France; FRANCIM Network, Toulouse F-31073, France. Electronic address: Valerie.jooste@u-bourgogne.fr.
Eur J Cancer ; 208: 114187, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39013266
ABSTRACT

BACKGROUND:

To estimate net survival and cancer cure fraction (CF), i.e. the proportion of patients no longer at risk of dying from cancer progression/relapse, a clear distinction needs to be made between mortality from cancer and from other causes. Conventionally, CF is estimated assuming no excess mortality compared to the general population.

METHODS:

A new modelling approach, that corrects for patients' extra risk of dying (RR) from causes other than the diagnosed cancer, was considered to estimate both indicators. We analysed EUROCARE-6 data on head and neck (H&N), colorectal, and breast cancer patients aged 40-79, diagnosed from 1998 to 2002 and followed-up to 31/12/2014, provided by 65 European cancer registries.

FINDINGS:

Young male H&N cancer patients have 4 times the risk of dying from other causes than their peers, this risk decreases with age to 1.6. Similar results were observed for female. We observed an absolute increase in CF of 30 % using the new model instead of the conventional one. For colorectal cancer, CF with the new model increased by a maximum of 3 % for older patients and the RR ranged from 1 to 1.2 for both sexes. CF of female breast cancer ranged from 73 % to 79 % using the new cure model, with RR between 1.2 and 1.4.

INTERPRETATION:

Not considering a RR> 1 leads to underestimate the proportion of patients not bound to die of their diagnosed cancer. Estimates of cancer mortality risk have an important impact on patients' quality of life.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Neoplasias Colorrectales / Neoplasias de Cabeza y Cuello Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Eur J Cancer Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Neoplasias Colorrectales / Neoplasias de Cabeza y Cuello Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Eur J Cancer Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido