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Light-Activated Nanocatalyst for Precise In-Situ Antimicrobial Synthesis via Photoredox-Catalytic Click Reaction.
Zhao, Minyang; Cao, Lei; Bai, Qingqing; Lu, Yaru; Li, Bowen; Wu, Wenbo; Ye, Jinzhou; Chen, Xinhan; Wang, Zhihong; Liu, Bin; Mao, Duo.
Afiliación
  • Zhao M; Department of Laboratory Medicine, Institute of Precision Medicine The First Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University, 1510080, Guangzhou, China.
  • Cao L; Department of Chemical and Biomolecular Engineering, National University of Singapore, 117585, Singapore, Singapore.
  • Bai Q; Joint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, 350207, Fuzhou, China.
  • Lu Y; Department of Laboratory Medicine, Institute of Precision Medicine The First Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University, 1510080, Guangzhou, China.
  • Li B; Department of Chemistry, Institute of Molecular Aggregation Science, Tianjin University, 300072, Tianjin, China.
  • Wu W; Institute of Transplant Medicine School of Medicine, Nankai University, 300071, Tianjin, China.
  • Ye J; Department of Chemistry, Institute of Molecular Aggregation Science, Tianjin University, 300072, Tianjin, China.
  • Chen X; Institute of Infectious Diseases, Shenzhen Bay Laboratory, 518132, Shenzhen, Guangdong, China.
  • Wang Z; Institute of Infectious Diseases, Shenzhen Bay Laboratory, 518132, Shenzhen, Guangdong, China.
  • Liu B; Institute of Transplant Medicine School of Medicine, Nankai University, 300071, Tianjin, China.
  • Mao D; Department of Chemical and Biomolecular Engineering, National University of Singapore, 117585, Singapore, Singapore.
Angew Chem Int Ed Engl ; 63(41): e202408918, 2024 Oct 07.
Article en En | MEDLINE | ID: mdl-39013139
ABSTRACT
The excessive and prolonged use of antibiotics contributes to the emergence of drug-resistant S. aureus strains and potential dysbacteriosis-related diseases, necessitating the exploration of alternative therapeutic approaches. Herein, we present a light-activated nanocatalyst for synthesizing in situ antimicrobials through photoredox-catalytic click reaction, achieving precise, site-directed elimination of S. aureus skin infections. Methylene blue (MB), a commercially available photosensitizer, was encapsulated within the CuII-based metal-organic framework, MOF-199, and further enveloped with Pluronic F-127 to create the light-responsive nanocatalyst MB@PMOF. Upon exposure to red light, MB participates in a photoredox-catalytic cycle, driven by the 1,3,5-benzenetricarboxylic carboxylate salts (BTC-) ligand presented in the structure of MOF-199. This light-activated MB then catalyzes the reduction of CuII to CuI through a single-electron transfer (SET) process, efficiently initiating the click reaction to form active antimicrobial agents under physiological conditions. Both in vitro and in vivo results demonstrated the effectiveness of MB@PMOF-catalyzed drug synthesis in inhibiting S. aureus, including their methicillin-resistant strains, thereby accelerating skin healing in severe bacterial infections. This study introduces a novel design paradigm for controlled, on-site drug synthesis, offering a promising alternative to realize precise treatment of bacterial infections without undesirable side effects.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Staphylococcus aureus / Química Clic / Luz / Antibacterianos Límite: Animals Idioma: En Revista: Angew Chem Int Ed Engl Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Staphylococcus aureus / Química Clic / Luz / Antibacterianos Límite: Animals Idioma: En Revista: Angew Chem Int Ed Engl Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania