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Nodal T follicular helper cell lymphoma with aberrant CD20 expression and monoclonal TCR, IG rearrangements secondary to Classical Hodgkin Lymphoma: a case report.
Zhu, Ning; Pan, Yu; Song, Liling; Li, Na; Sui, Xiaolong; Yang, Ping; Liu, Xiaoqian; Zhang, Li; Yu, Guohua.
Afiliación
  • Zhu N; Department of Pathology, College of Basic Medical Sciences, Binzhou Medical University, Yantai, 264003, Shandong, China.
  • Pan Y; Department of Pathology, Yantai Yuhuangding Hospital, 20 Yudong Road Zhifu District, Yantai, 264000, Shandong, China.
  • Song L; The Clinical Medicine School of Shandong, Second Medical University, Weifang, 261000, Shandong, China.
  • Li N; The Second Medical College of Binzhou Medical University, Yantai, 264003, Shandong, China.
  • Sui X; The Second Medical College of Binzhou Medical University, Yantai, 264003, Shandong, China.
  • Yang P; Department of Pathology, Yantai Yuhuangding Hospital, 20 Yudong Road Zhifu District, Yantai, 264000, Shandong, China.
  • Liu X; Department of Pathology, Yantai Yuhuangding Hospital, 20 Yudong Road Zhifu District, Yantai, 264000, Shandong, China.
  • Zhang L; Department of Hematology, Yantai Yuhuangding Hospital, Yantai, 264000, Shandong, China.
  • Yu G; Department of Pathology, Yantai Yuhuangding Hospital, 20 Yudong Road Zhifu District, Yantai, 264000, Shandong, China. sar86127@163.com.
Med Mol Morphol ; 2024 Jul 16.
Article en En | MEDLINE | ID: mdl-39012522
ABSTRACT
Classical Hodgkin Lymphoma (CHL) is a rare malignant neoplasm of the lymphatic system. While CHL typically responds well to conventional treatments, some cases may experience relapse to other subtypes, with the development of secondary peripheral T-cell lymphoma (PTCL) being relatively uncommon. Herein, we report a rare case of nodal T follicular helper cell lymphomas,nos (nTFHL-NOS) secondary to CHL, accompanied by aberrant CD20 expression and clonal rearrangements of T-cell receptor (TCR) and immunoglobulin (IG). A 74-year-old male, was diagnosed with CHL, leaning toward the mixed cell type, 6 years ago. He received six cycles of the Adriamycin, Bleomycin, Vinblastine, Dacarbazine (ABVD) regimen, achieving complete clinical remission. The patient was admitted to our hospital due to the appearance of multiple skin nodules 66 months later. Histopathological analysis revealed nTFHL-NOS, with aberrant CD20 expression and clonal rearrangements of TCR and IG. The patient underwent two cycles of chemotherapy with brentuximab vedotin and the Gemcitabine-Oxaliplatin (G-mox) regimen, resulting in a reduction of the skin lesions to 2 cm × 1 cm. We discuss this rare case and review related literature.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Med Mol Morphol Asunto de la revista: BIOLOGIA MOLECULAR / PATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Med Mol Morphol Asunto de la revista: BIOLOGIA MOLECULAR / PATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Japón