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Antimicrobial resistance in food-borne pathogens at the human-animal interface: Results from a large surveillance study in India.
Mahindroo, Jaspreet; Narayan, Chandradeo; Modgil, Vinay; Kaur, Harpreet; Shahi, Varun; Sharma, Bhawna; Jain, Ruby; Thakur, Siddhartha; Mohan, Balvinder; Taneja, Neelam.
Afiliación
  • Mahindroo J; Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh 1610012, India.
  • Narayan C; MRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, UK.
  • Modgil V; Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh 1610012, India.
  • Kaur H; Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh 1610012, India.
  • Shahi V; Society for Health Information Systems Programmes (HISP), India.
  • Sharma B; Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh 1610012, India.
  • Jain R; Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh 1610012, India.
  • Thakur S; Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh 1610012, India.
  • Mohan B; Department of Microbiology, AIIMS, Bathinda, Punjab 151001, India.
  • Taneja N; Civil Hospital Manimajra, Chandigarh, Panchkula, India.
One Health ; 18: 100677, 2024 Jun.
Article en En | MEDLINE | ID: mdl-39010970
ABSTRACT

Background:

The burden of foodborne diseases and antimicrobial resistance carried by key foodborne pathogens in India is unknown due to a lack of an integrated surveillance system at the human-animal interface.

Methods:

We present data from the WHO-AGISAR (Advisory Group on Integrated Surveillance of Antimicrobial Resistance), India project. Concurrent human and animal sampling was done across a large area across north India. Community-acquired diarrhea cases (n = 1968) of all age groups were included. Cross-sectional sampling of stool/ intestinal contents (n = 487) and meat samples (n = 419) from food-producing animals was done at farms, retail shops, and slaughterhouses. Pathogens were cultured and identified, and antimicrobial susceptibility was performed.

Results:

Over 80% of diarrhoeal samples were obtained from moderate to severe diarrhea patients, which yielded EAEC (5%), ETEC (4.84%), EPEC (4.32%), and Campylobacter spp. (2%). A high carriage of EPEC (32.11%) and Campylobacter spp. (24.72%) was noted in food animals, but the prevalence of ETEC (2%) and EAEC (1%) was low. Atypical EPEC (aEPEC, 84.52%, p ≤0.0001) were predominant and caused milder diarrhea. All EPEC from animal/poultry were aEPEC. Overall, a very high level of resistance was observed, and the MDR rate ranged from 29.2% in Campylobacter spp., 53.6% in EPEC, and 59.8% in ETEC. Resistance to piperacillin-tazobactam, cefepime, ceftriaxone, and co-trimoxazole was significantly higher in human strains. In contrast, resistance to ciprofloxacin, aminoglycosides, and tetracycline was higher in animal strains, reflecting the corresponding usage in human and animal sectors. ESBL production was commoner in animal isolates than in humans, indicating high use of third-generation cephalosporins in the animal sector. C. hyointestinalis is an emerging zoonotic pathogen, first time reported from India.

Conclusion:

In one of the most extensive studies from India, a high burden of key foodborne pathogens with MDR and ESBL phenotypes was found in livestock, poultry, and retail meat.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: One Health Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: One Health Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos