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Stochastic journeys of cell progenies through compartments and the role of self-renewal, symmetric and asymmetric division.
Dreiwi, Hanan; Feliciangeli, Flavia; Castro, Mario; Lythe, Grant; Molina-París, Carmen; López-García, Martín.
Afiliación
  • Dreiwi H; School of Mathematics, University of Leeds, Leeds, UK.
  • Feliciangeli F; School of Mathematics, University of Leeds, Leeds, UK.
  • Castro M; Systems Pharmacology and Medicine, Bayer AG, Leverkusen, Germany.
  • Lythe G; Grupo Interdisciplinar de Sistemas Complejos (GISC), Instituto de Investigación Tecnológica (IIT), Universidad Pontificia Comillas, Madrid, Spain.
  • Molina-París C; School of Mathematics, University of Leeds, Leeds, UK.
  • López-García M; School of Mathematics, University of Leeds, Leeds, UK.
Sci Rep ; 14(1): 16287, 2024 07 15.
Article en En | MEDLINE | ID: mdl-39009631
ABSTRACT
Division and differentiation events by which cell populations with specific functions are generated often take place as part of a developmental programme, which can be represented by a sequence of compartments. A compartment is the set of cells with common characteristics; sharing, for instance, a spatial location or a phenotype. Differentiation events are transitions from one compartment to the next. Cells may also die or divide. We consider three different types of division events (i) where both daughter cells inherit the mother's phenotype (self-renewal), (ii) where only one of the daughters changes phenotype (asymmetric division), and (iii) where both daughters change phenotype (symmetric division). The self-renewal probability in each compartment determines whether the progeny of a single cell, moving through the sequence of compartments, is finite or grows without bound. We analyse the progeny stochastic dynamics with probability generating functions. In the case of self-renewal, by following one of the daughters after any division event, we may construct lifelines containing only one cell at any time. We analyse the number of divisions along such lines, and the compartment where lines terminate with a death event. Analysis and numerical simulations are applied to a five-compartment model of the gradual differentiation of hematopoietic stem cells and to a model of thymocyte development from pre-double positive to single positive (SP) cells with a bifurcation to either SP4 or SP8 in the last compartment of the sequence.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diferenciación Celular / División Celular / Procesos Estocásticos Límite: Animals / Humans Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diferenciación Celular / División Celular / Procesos Estocásticos Límite: Animals / Humans Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido