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Quantitative assessment of cardiac 123iodo-metaiodobenzylguanidine SPECT/CT in patients with arrhythmogenic right ventricular cardiomyopathy: Novel insight in disease monitoring.
Hagen, Johannes M; Zacherl, Mathias J; Brendel, Matthias; Clauß, Sebastian; Kääb, Stefan; Bartenstein, Peter; Todica, Andrei; Böning, Guido; Fischer, Maximilian.
Afiliación
  • Hagen JM; Department of Nuclear Medicine, Ludwig-Maximilians-University, Munich 81377, Germany.
  • Zacherl MJ; Department of Nuclear Medicine, Ludwig-Maximilians-University, Munich 81377, Germany.
  • Brendel M; Department of Nuclear Medicine, Ludwig-Maximilians-University, Munich 81377, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
  • Clauß S; Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Ludwig-Maximilians-Universität, Marchioninistrasse 15, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany; Institute of Surgical Research at the Walter-Br
  • Kääb S; Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Ludwig-Maximilians-Universität, Marchioninistrasse 15, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany; Institute of Surgical Research at the Walter-Br
  • Bartenstein P; Department of Nuclear Medicine, Ludwig-Maximilians-University, Munich 81377, Germany.
  • Todica A; Department of Nuclear Medicine, Ludwig-Maximilians-University, Munich 81377, Germany.
  • Böning G; Department of Nuclear Medicine, Ludwig-Maximilians-University, Munich 81377, Germany.
  • Fischer M; Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Ludwig-Maximilians-Universität, Marchioninistrasse 15, 81377 Munich, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany. Electronic address: Maximilian.Fischer@med.uni-
J Nucl Cardiol ; 39: 101911, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39009215
ABSTRACT

BACKGROUND:

The heart-to-mediastinum ratio (H/M-Ratio) of 123iodo-metaiodobenzylguanidine (123I-MIBG) represents state-of-the-art assessment for sympathetic dysfunction in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). This study aims to evaluate quantitative reconstruction of 123I-MIBG uptake and to demonstrate its correlation with echocardiographic parameters.

METHODS:

Cardiac innervation was assessed in 23 patients diagnosed with definite ARVC or borderline ARVC and 12 patients with other cardiac disease presenting arrhythmia, using quantitative 123I-MIBG Single Photon Emission Computed Tomography/Computed Tomography (SPECT/CT) imaging. Tracer uptake was evaluated in the left (LV) and right ventricle (RV) based on a CT scan after quantitative image reconstruction. The relationship between tracer uptake and echocardiographic parameter data was examined.

RESULTS:

Absolute quantification of 123I-MIBG uptake in the LV and RV is feasible and correlates accurately with the gold standard H/M Ratio. When comparing sensitivity and specificity, the area under the curve (AUC) favors standardized uptake value (SUV) of the RV over the right-ventricle-to-mediastinum-ratio (RV/M-Ratio) for diagnosing ARVC. A reduced RV-SUV in patients with definite ARVC is associated with reduced RV function. RV polar maps revealed globally reduced 123I-MIBG uptake without segment-specific reduction in the RV.

CONCLUSIONS:

Quantitative 123I-MIBG SPECT in ARCV patients offers robust potential for clinical reporting and demonstrates a significant correlation with RV function. Segmental RV analysis needs to be evaluated in larger samples. In summary, cardiac 123I-MIBG imaging using SUV could facilitate image-guided therapy in patients diagnosed with ARVC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Radiofármacos / Displasia Ventricular Derecha Arritmogénica / 3-Yodobencilguanidina / Tomografía Computarizada por Tomografía Computarizada de Emisión de Fotón Único Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Nucl Cardiol Asunto de la revista: CARDIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Radiofármacos / Displasia Ventricular Derecha Arritmogénica / 3-Yodobencilguanidina / Tomografía Computarizada por Tomografía Computarizada de Emisión de Fotón Único Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Nucl Cardiol Asunto de la revista: CARDIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos