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Longitudinal changes in mitochondrial-associated measures and insulin resistance in youth with perinatally-acquired HIV in the U.S.
Gojanovich, Greg S; Yu, Wendy; Zhang, Zhongli J; Jacobson, Denise L; Yao, Tzy-Jyun; Jao, Jennifer; Libutti, Daniel E; Geffner, Mitchell E; Gerschenson, Mariana.
Afiliación
  • Gojanovich GS; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
  • Yu W; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  • Zhang ZJ; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  • Jacobson DL; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  • Yao TJ; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  • Jao J; Department of Pediatrics, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60642, USA.
  • Libutti DE; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
  • Geffner ME; Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
  • Gerschenson M; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
Mitochondrion ; 78: 101936, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39009104
ABSTRACT
HIV infection and its treatment are associated with mitochondrial dysfunction and metabolic derangement. However, longitudinal changes in oxidative phosphorylation activities [Complex I (C1) and Complex IV (C4)], or venous lactate/pyruvate ratios (LPR), and their relationships with insulin resistance (IR), remain unclear in youth living with perinatally-acquired HIV (YPHIV). We measured venous LPR, C1, and C4 activities in blood cells and homeostatic model assessment for IR (HOMA-IR) over two years. Limited longitudinal differences in mitochondrial-related measures and IR were observed in YPHIV vs youth perinatally HIV-exposed but uninfected. There were no systematic differences in C1, C4, or HOMA-IR between the groups.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Infecciones por VIH Límite: Adolescent / Adult / Child / Female / Humans / Male País/Región como asunto: America do norte Idioma: En Revista: Mitochondrion Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Infecciones por VIH Límite: Adolescent / Adult / Child / Female / Humans / Male País/Región como asunto: America do norte Idioma: En Revista: Mitochondrion Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos