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Comparison of nylon, vicryl, and fibrin glue for nerve grafting in rats.
Hanna, Amgad S; Mickelson, Ethan; Omar, Ahmed H; Baer, Matthew; Sveum, Jacob; Marti, Taylor; Mishra, Raveena; Trudrung, Melissa; Hutchinson, Jacob; Attaluri, Pradeep; Jacobs, Alison; Ott, Emily; Martinson, Natalie; Jones, Jalon; Hellenbrand, Daniel.
Afiliación
  • Hanna AS; Department of Neurological Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
  • Mickelson E; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA.
  • Omar AH; Department of Neurological Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
  • Baer M; Department of Neurological Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
  • Sveum J; Faculty of Medicine, Cairo University, Giza, Egypt.
  • Marti T; Department of Neurological Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
  • Mishra R; Department of Neurological Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
  • Trudrung M; Department of Neurological Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
  • Hutchinson J; Department of Neurological Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
  • Attaluri P; Department of Neurological Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
  • Jacobs A; Department of Neurological Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
  • Ott E; Division of Plastic Surgery, Department of General Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
  • Martinson N; Department of Neurological Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
  • Jones J; Department of Neurological Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
  • Hellenbrand D; Department of Neurological Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Neurol Res ; 46(10): 972-981, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39007696
ABSTRACT

OBJECTIVES:

For nerve injuries, not amendable to tensionless epineural coaptation of the nerve, autografts are the preferred treatment. Although absorbable sutures are not recommended for nerve repair, there is no evidence that non-absorbable sutures are superior to absorbable sutures. This study aims to assess the effectiveness of non-absorbable monofilament nylon sutures, absorbable monofilament vicryl sutures, and fibrin glue when used for nerve grafting.

METHODS:

Lewis rats (N = 32) were subjected to a sciatic nerve transection and randomly assigned to a group graft with Nylon, graft with Vicryl, graft with Fibrin Glue, or no graft. Motor function, sensory function, and thermal pain were assessed during a 12-week recovery period, and immunohistochemistry was used to assess macrophage response.

RESULTS:

At 12 weeks, the Vicryl and Nylon groups had significantly larger ankle angles at to lift off, which is a measure of motor function, compared to injured controls (p < 0.05). Grafted rats displayed no difference in thermal response but hypersensitivity to mechanical stimuli compared to the uninjured hindlimb. The Nylon, Vicryl, and Fibrin Glue groups all had significantly less atrophy of the gastrocnemius muscle compared to injured controls (p < 0.0001). In the Fibrin Glue group, 3/9 grafts did not incorporate. The Nylon group had significantly less (p = 0.0004) axon growth surrounding the suture holes compared to the Vicryl group. There were no differences in the axon counts, motor neurons, or sensory neurons between all grafted rats.

CONCLUSIONS:

These results demonstrate that vicryl sutures work just as well as nylon for nerve recovery after injury and grafting.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliglactina 910 / Ratas Endogámicas Lew / Adhesivo de Tejido de Fibrina / Nylons Límite: Animals Idioma: En Revista: Neurol Res Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliglactina 910 / Ratas Endogámicas Lew / Adhesivo de Tejido de Fibrina / Nylons Límite: Animals Idioma: En Revista: Neurol Res Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido