Rhodium(III)-Catalyzed Intramolecular Cyclization and Sequential Aromatization of Ynamides with Propargyl Esters: Access to 2,5-Dihydropyrroles and Pyrroles.

Yang, Jin-Ming; Feng, Guang-Chao; Huang, Xiang; Wang, Yi-Lin; Wei, Qing-Yi; Wu, Bin

Yang, Jin-Ming; Feng, Guang-Chao; Huang, Xiang; Wang, Yi-Lin; Wei, Qing-Yi; Wu, Bin.

Afiliación

Yang JM; School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, Hubei 430074, People's Republic of China.
Feng GC; School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, Hubei 430074, People's Republic of China.
Huang X; School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, Hubei 430074, People's Republic of China.
Wang YL; School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, Hubei 430074, People's Republic of China.
Wei QY; School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, Hubei 430074, People's Republic of China.
Wu B; School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, Hubei 430074, People's Republic of China.

Org Lett ; 26(29): 6191-6196, 2024 Jul 26.

Article en En | MEDLINE | ID: mdl-39007534

ABSTRACT

ABSTRACT

Disclosed herein is a rhodium(III)-catalyzed intramolecular cyclization of ynamides with propargyl esters. A variety of highly functionalized 2,5-dihydropyrroles were obtained in moderate to good yields with high E/Z selectivities. Subsequent oxidation of the products gave valuable pyrrole derivatives. Additionally, scale-up reactions and late-stage derivatizations highlight the potential synthetic utility of this methodology.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos

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