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Ethnic differences in the effects of apolipoprotein E ɛ4 and vascular risk factors on accelerated brain aging.
Im, Yanghee; Kang, Sung Hoon; Park, Gilsoon; Yoo, Heejin; Chun, Min Young; Kim, Chi-Hun; Park, Chae Jung; Kim, Jun Pyo; Jang, Hyemin; Kim, Hee Jin; Oh, Kyungmi; Koh, Seong-Beom; Lee, Jong-Min; Na, Duk L; Seo, Sang Won; Kim, Hosung.
Afiliación
  • Im Y; USC Steven Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA.
  • Kang SH; Department of Biomedical Engineering, Hanyang University, Seoul 04763, Korea.
  • Park G; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
  • Yoo H; Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul 08308, Korea.
  • Chun MY; USC Steven Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA.
  • Kim CH; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
  • Park CJ; Department of Neurology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin 16995, Korea.
  • Kim JP; Department of Neurology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Korea.
  • Jang H; Research Institute, National Cancer Center, Goyang 10408, Korea.
  • Kim HJ; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
  • Oh K; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
  • Koh SB; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
  • Lee JM; Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul 08308, Korea.
  • Na DL; Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul 08308, Korea.
  • Seo SW; Department of Biomedical Engineering, Hanyang University, Seoul 04763, Korea.
  • Kim H; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
Brain Commun ; 6(4): fcae213, 2024.
Article en En | MEDLINE | ID: mdl-39007039
ABSTRACT
The frequency of the apolipoprotein E ɛ4 allele and vascular risk factors differs among ethnic groups. We aimed to assess the combined effects of apolipoprotein E ɛ4 and vascular risk factors on brain age in Korean and UK cognitively unimpaired populations. We also aimed to determine the differences in the combined effects between the two populations. We enrolled 2314 cognitively unimpaired individuals aged ≥45 years from Korea and 6942 cognitively unimpaired individuals from the UK, who were matched using propensity scores. Brain age was defined using the brain age index. The apolipoprotein E genotype (ɛ4 carriers, ɛ2 carriers and ɛ3/ɛ3 homozygotes) and vascular risk factors (age, hypertension and diabetes) were considered predictors. Apolipoprotein E ɛ4 carriers in the Korean (ß = 0.511, P = 0.012) and UK (ß = 0.302, P = 0.006) groups had higher brain age index values. The adverse effects of the apolipoprotein E genotype on brain age index values increased with age in the Korean group alone (ɛ2 carriers × age, ß = 0.085, P = 0.009; ɛ4 carriers × age, ß = 0.100, P < 0.001). The apolipoprotein E genotype, age and ethnicity showed a three-way interaction with the brain age index (ɛ2 carriers × age × ethnicity, ß = 0.091, P = 0.022; ɛ4 carriers × age × ethnicity, ß = 0.093, P = 0.003). The effects of apolipoprotein E on the brain age index values were more pronounced in individuals with hypertension in the Korean group alone (ɛ4 carriers × hypertension, ß = 0.777, P = 0.038). The apolipoprotein E genotype, age and ethnicity showed a three-way interaction with the brain age index (ɛ4 carriers × hypertension × ethnicity, ß=1.091, P = 0.014). We highlight the ethnic differences in the combined effects of the apolipoprotein E ɛ4 genotype and vascular risk factors on accelerated brain age. These findings emphasize the need for ethnicity-specific strategies to mitigate apolipoprotein E ɛ4-related brain aging in cognitively unimpaired individuals.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Commun Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Commun Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido