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Effect of smoking cessation on the likelihood of pancreatitis and pancreatic cancer.
Han, Xiao; Xu, Zouhua; Ma, Dongmei; Ling, Zhi; Dong, Xiaowu; Yan, Xuebing; Chen, Yong; Lu, Guotao; Yin, Xudong; Xu, Hongwei.
Afiliación
  • Han X; Department of Oncology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
  • Xu Z; Yangzhou Key Laboratory of Pancreatic Diseases, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
  • Ma D; Kunshan Hospital of Traditional Chinese Medicine, Kunshan Affiliated Hospital of Yangzhou University, Yangzhou University, Kunshan, China.
  • Ling Z; Department of Oncology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
  • Dong X; Department of Oncology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
  • Yan X; Yangzhou Key Laboratory of Pancreatic Diseases, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
  • Chen Y; Pancreatic Center, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
  • Lu G; Department of Oncology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
  • Yin X; Department of Oncology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
  • Xu H; Yangzhou Key Laboratory of Pancreatic Diseases, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Tob Induc Dis ; 222024.
Article en En | MEDLINE | ID: mdl-39006371
ABSTRACT

INTRODUCTION:

Tobacco smoking is a major risk factor for various diseases worldwide, including pancreatic exocrine diseases such as pancreatitis and pancreatic cancer (PC). Currently, few studies have examined the impact of smoking cessation on the likelihood of common pancreatic exocrine diseases. This study sought to determine whether smoking cessation would reduce pancreatitis and PC morbidity.

METHODS:

This cohort study used data from the UK Biobank (UKB) to examine the association between smoking status and the likelihood of pancreatitis and PC among 492855 participants. The subjects were divided into never smokers, ex-smokers, and current smokers. Using a multivariate-adjusted binary logistic regression model, we analyzed the relationship between different smoking conditions and the likelihood of pancreatitis and PC. Further, we studied the impact of smoking cessation on pancreatitis and PC compared with current smoking.

RESULTS:

After adjusting for potential confounders, current smokers had higher odds for acute pancreatitis (AP) (AOR=1.38; 95% CI 1.18-1.61), chronic pancreatitis (CP) (AOR=3.29; 95% CI 2.35-4.62) and PC (AOR=1.72; 95% CI 1.42-2.09). People who quit smoking had comparable odds for the diseases as those who never smoked. Compared with current smokers, ex-smokers had reduced odds for AP (AOR=0.76; 95% CI 0.64-0.89), CP (AOR=0.31; 95% CI 0.21-0.46), and PC (AOR=0.62; 95% CI 0.50-0.76). Subgroup analysis revealed reduced odds for these pancreatic diseases in males and females.

CONCLUSIONS:

Smokers have an increased odds for pancreatitis and pancreatic cancer. Moreover, smoking cessation can significantly reduce the odds for acute pancreatitis, chronic pancreatitis and pancreatic cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Tob Induc Dis Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Grecia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Tob Induc Dis Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Grecia