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Altered connectivity between frontal cortex and supplementary motor area in various types of Parkinson's disease.
Xing, Fengbo; Feng, Jingjing; Lv, Lingling; Liu, Jiaqiu; Chen, Xin; Sun, Jinmei; Hu, Panpan; Wang, Kai.
Afiliación
  • Xing F; Department of Neurology, The First Affiliated Hospital of Anhui Medical University Hefei 230000, Anhui, China.
  • Feng J; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders Hefei 230032, Anhui, China.
  • Lv L; Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health Hefei 230000, Anhui, China.
  • Liu J; Department of Neurology, The First Affiliated Hospital of Anhui Medical University Hefei 230000, Anhui, China.
  • Chen X; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders Hefei 230032, Anhui, China.
  • Sun J; Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health Hefei 230000, Anhui, China.
  • Hu P; Department of Neurology, The First Affiliated Hospital of Anhui Medical University Hefei 230000, Anhui, China.
  • Wang K; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders Hefei 230032, Anhui, China.
Am J Transl Res ; 16(6): 2423-2434, 2024.
Article en En | MEDLINE | ID: mdl-39006296
ABSTRACT

BACKGROUND:

Tremor-dominant (TD) and postural instability/gait difficulty (PIGD) are common subtypes of Parkinson's disease, each with distinct clinical manifestations and prognoses. The neural mechanisms underlying these subtypes remain unclear. This study aimed to investigate the altered connectivity of the frontal cortex and supplementary motor area (SMA) in different types of Parkinson's disease.

METHODS:

Data of 173 participants, including 41 TD patients, 65 PIGD patients, and 67 healthy controls, were retrospectively analyzed. All subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI) and clinical assessments. Differences in amplitude of low frequency fluctuation (ALFF), voxel-wise functional connectivity (FC), and functional network connectivity (FNC) among the three groups were compared, followed by partial correlation analysis.

RESULTS:

Compared to healthy controls, the left dorsolateral superior frontal gyrus (DLSFG) ALFF was significantly increased in both PIGD and TD patients. The FC between the left DLSFG and the left SMA, as well as between the left paracentral lobule and the right DLSFG, was significantly decreased. Similarly, the FNC between the visual network and the auditory network was reduced. Compared to TD patients, PIGD patients showed a significantly higher ALFF in the left DLSFG and a notably reduced FC between the left DLSFG and left SMA. Additionally, the FC of the left DLSFG-SMA was inversely correlated with the PIGD score exclusively in PIGD patients. The FNC of the visual-auditory network was inversely associated with the tremor score only in TD patients.

CONCLUSION:

Decreases in the left DLSFG-SMA connectivity may be a key feature of the PIGD subtype, while reduced VN-AUD connectivity may characterize the TD subtype.
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Transl Res Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Transl Res Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos