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Applications of CRISPR in Parasitology.
Tee, Phoebe Yon Ern; Chu, Sylvester Yee Chun; Kok, Chloe Chien Yee; Foo, Mun; Tan, Clarence Zhen Jin; Foo, Jhi Biau; Mohd Hatta, Fazleen Haslinda; Tan, Li Kar Stella; Hamzah, Sharina.
Afiliación
  • Tee PYE; School of Biosciences, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Selangor, 47500, Malaysia.
  • Chu SYC; School of Biosciences, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Selangor, 47500, Malaysia.
  • Kok CCY; School of Biosciences, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Selangor, 47500, Malaysia.
  • Foo M; School of Biosciences, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Selangor, 47500, Malaysia.
  • Tan CZJ; School of Biosciences, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Selangor, 47500, Malaysia.
  • Foo JB; School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Selangor, 47500, Malaysia.
  • Mohd Hatta FH; Digital Health & Medical Advancement Impact Lab, Taylor's University, 47500, Subang Jaya, Selangor, Malaysia.
  • Tan LKS; Faculty of Pharmacy, Universiti Teknologi MARA UiTM, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia.
  • Hamzah S; School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Selangor, 47500, Malaysia.
Curr Pharm Biotechnol ; 2024 Jul 12.
Article en En | MEDLINE | ID: mdl-39005116
ABSTRACT
Clustered Regions of Interspersed Palindromic Repeat (CRISPR)-based techniques have been utilized in various research areas, including agriculture, biotechnology, and medicine. With the use of a short sequence guide RNA and CRISPR-associated (Cas) protein, this technique allows for robust, site-specific manipulation of the genome, aiding researchers in making important biomedical discoveries and scientific advancements. In this review, we explored the applications of CRISPR/Cas systems in the field of parasitology for the identification and validation of novel functional genes, diagnosis of parasitic infections, reduction of parasite virulence, and the disruption of disease transmission. We also discussed how CRISPR can be used for the development of therapeutics, vaccines, and drug discovery. Furthermore, the challenges and future perspectives of this technology are also highlighted.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Pharm Biotechnol Asunto de la revista: BIOTECNOLOGIA / FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Pharm Biotechnol Asunto de la revista: BIOTECNOLOGIA / FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Países Bajos