Your browser doesn't support javascript.
loading
GP consultations for menstrual disorders after COVID-19 vaccination - A self-controlled cohort study based on routine healthcare data from the Netherlands.
Jajou, R; Lieber, T; van Puijenbroek, E P; Mulder, E; Overbeek, J; Hek, K; van Hunsel, F P A M; Kant, A.
Afiliación
  • Jajou R; Netherlands Pharmacovigilance Centre Lareb, 's-Hertogenbosch, Netherlands.
  • Lieber T; Netherlands Pharmacovigilance Centre Lareb, 's-Hertogenbosch, Netherlands.
  • van Puijenbroek EP; Netherlands Pharmacovigilance Centre Lareb, 's-Hertogenbosch, Netherlands; Department of PharmacoTherapy, Epidemiology and Economics, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Groningen, Netherlands.
  • Mulder E; Netherlands Pharmacovigilance Centre Lareb, 's-Hertogenbosch, Netherlands.
  • Overbeek J; PHARMO Institute for Drug Outcomes Research, Utrecht, Netherlands.
  • Hek K; Nivel (Netherlands Institute for Health Services Research), Utrecht, Netherlands.
  • van Hunsel FPAM; Netherlands Pharmacovigilance Centre Lareb, 's-Hertogenbosch, Netherlands; Department of PharmacoTherapy, Epidemiology and Economics, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Groningen, Netherlands.
  • Kant A; Netherlands Pharmacovigilance Centre Lareb, 's-Hertogenbosch, Netherlands; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, Netherlands. Electronic address: a.kant@lareb.nl.
Vaccine ; 42(25): 126130, 2024 Nov 14.
Article en En | MEDLINE | ID: mdl-39004527
ABSTRACT

INTRODUCTION:

Several studies described that COVID-19 vaccinations can cause menstrual disorders. Our study aimed to describe whether this also resulted in more general practitioner (GP) consultations for menstrual disorders after COVID-19 vaccination, based on a large cohort study.

METHODS:

A retrospective self-controlled cohort study was performed including vaccinated women in 2021 aged 12-49 years from two large, representative GP databases in the Netherlands. Incidence rates and incidence rate ratio's (IRR) were calculated using Poisson regression, adjusting for SARS-CoV-2 infection as time-varying confounder. The exposed period was set at maximum six months after each COVID-19 vaccination and the non-exposed period was defined as all-time outside the exposed period.

RESULTS:

The cohort included 631,802 women, of which 18,986 (3 %) consulted the GP for a menstrual disorder during 2021. Increased GP consultations were observed among 12-14 year olds for amenorrhea/hypomenorrhea/oligomenorrhea (IRR 1.85, 95 % CI 1.30-2.65) and irregular/frequent menstruation (IRR 1.33, 95 % CI 1.06-1.69) after COVID-19 vaccination in general, and after Pfizer/BioNTech vaccination (IRR 1.87, 95 % CI 1.31-2.67 for amenorrhea/hypomenorrhea/oligomenorrhea and IRR 1.35, 95 % CI 1.06-1.70 for irregular/frequent menstruation). Persons from this age group were in general also vaccinated with Pfizer/BioNTech. No increase in the frequency of GP consultations were observed for older age groups, other vaccine brands, and potential risk groups.

CONCLUSION:

For the majority of women, no increased GP consultations for menstrual disorders was found. Solely for the youngest age group (12-14 year olds) increased GP consultations for specific types of menstrual disorders was found after Pfizer/BioNTech vaccination.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunación / Vacunas contra la COVID-19 / COVID-19 Límite: Adolescent / Adult / Child / Female / Humans / Middle aged País/Región como asunto: Europa Idioma: En Revista: Vaccine Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunación / Vacunas contra la COVID-19 / COVID-19 Límite: Adolescent / Adult / Child / Female / Humans / Middle aged País/Región como asunto: Europa Idioma: En Revista: Vaccine Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Países Bajos