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In vivo evaluation by oral administration of chitosan combined with bioactive glass against cadmium-induced toxicity in rats.
Ait Hamdan, Youssef; Ait Baba, Abdelfatah; Azraida, Hajar; Kabdy, Hamid; Oudadesse, Hassane; Chait, Abderrahman; Rhazi, Mohammed.
Afiliación
  • Ait Hamdan Y; Interdisciplinary Laboratory in Bio-Resources, Environment and Materials, Higher Normal School, Cadi Ayyad University, 4000 Marrakech, Morocco; Univ Rennes, CNRS, ISCR-UMR 6226, F-35000 Rennes, France. Electronic address: youssef.aithamdan@univ-rennes1.fr.
  • Ait Baba A; Laboratory of Pharmacology, Neurobiology, Anthropobiology and Environment, Departement of Biology, Faculty of Sciences Semlalia, Cadi Ayyad University, Marrakesh 40000, Morocco.
  • Azraida H; Laboratory of Pharmacology, Neurobiology, Anthropobiology and Environment, Departement of Biology, Faculty of Sciences Semlalia, Cadi Ayyad University, Marrakesh 40000, Morocco.
  • Kabdy H; Laboratory of Pharmacology, Neurobiology, Anthropobiology and Environment, Departement of Biology, Faculty of Sciences Semlalia, Cadi Ayyad University, Marrakesh 40000, Morocco.
  • Oudadesse H; Univ Rennes, CNRS, ISCR-UMR 6226, F-35000 Rennes, France.
  • Chait A; Laboratory of Pharmacology, Neurobiology, Anthropobiology and Environment, Departement of Biology, Faculty of Sciences Semlalia, Cadi Ayyad University, Marrakesh 40000, Morocco.
  • Rhazi M; Interdisciplinary Laboratory in Bio-Resources, Environment and Materials, Higher Normal School, Cadi Ayyad University, 4000 Marrakech, Morocco.
Int J Biol Macromol ; 276(Pt 1): 133845, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39004258
ABSTRACT
Bioactive glass and chitosan are biomaterials widely used for orthopedic applications, notably as bone grafts. Although these biomaterials show promising therapeutic properties, no research has yet examined their potential for oral administration in soft tissue protection, particularly against metal toxicity. The aim of our study was to evaluate the potential of chitosan from cuttlefish (CHS) bone combined with bioactive glass (BG) against Cadmium-induced toxicity in rats. Cadmium (Cd), a heavy metal that accumulates in tissues, causes various disorders. Experiments were carried out on rats intoxicated acutely by oral administration of Cd (20 mg/kg body weight) and/or concomitantly with oral administration of CHS/BG (100 mg/kg body weight) for 7 days. Using pathophysiological and biochemical tests, we evaluated the detoxifying effect of orally administered CHS/BG against Cd toxicity. Our results showed, for the first time, a significant detoxifying effect of CHS/BG against Cd-induced toxicity in rats. Treatment with CHS/BG protected rats against the harmful effects of Cd by reducing lipid peroxidation levels and enhancing antioxidant enzyme activities. In addition, it helped restore phosphocalcic balance and protect liver, kidney and brain function. Remarkably, it also reduced Cd levels in the liver, kidneys and brain, as well as in the bones of rats. These results show that oral administration of CHS/BG has a strong therapeutic potential on tissues through detoxification of cadmium-exposed rats.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cadmio / Quitosano Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cadmio / Quitosano Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos