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Jasminum grandiflorum oral gel as an add-on to standard of care in radiation induced grade 2 oral mucositis - an open label pilot clinical trial.
Anuja, A R; Anoop, R; Mohanan, Arun; Ramesh, N V.
Afiliación
  • Anuja AR; Department of Rasashastra and Bhaishajya Kalpana (Pharmaceuticals), Amrita School of Ayurveda, Amritapuri, Amrita Vishwa Vidyapeetham, India.
  • Anoop R; Department of Radiation Oncology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.
  • Mohanan A; Department of Rasashastra and Bhaishajya Kalpana (Pharmaceuticals), Amrita School of Ayurveda, Amritapuri, Amrita Vishwa Vidyapeetham, India.
  • Ramesh NV; Department of Rasashastra and Bhaishajya Kalpana (Pharmaceuticals), Amrita School of Ayurveda, Amritapuri, Amrita Vishwa Vidyapeetham, India. Electronic address: drramesh.adiga@gmail.com.
J Ayurveda Integr Med ; 15(4): 100925, 2024.
Article en En | MEDLINE | ID: mdl-39003915
ABSTRACT

BACKGROUND:

Radiation-induced oral mucositis is one of the most critical dose-limiting toxicities associated with radiation therapy for oral cancer which can result in treatment interruption and compromise the quality of the life of cancer patients. Jati (Jasminum grandiflorum) is used in Ayurveda to treat oral conditions like stomatitis and mouth ulcers.

OBJECTIVE:

To test the feasibility of Jati oral gel as an add on therapy in grade 2 radiation-induced oral mucositis. MATERIALS AND

METHODS:

A prospective, open-label, non-randomised pilot trial was conducted on 20 patients with grade 2 radiation-induced oral mucositis at a tertiary cancer hospital. The control group received sodium bicarbonate mouthwash 4-5 times daily as the standard of care, while the intervention arm also received Jati oral gel twice daily. We used the ImageJ software for objective assessment and the Visual Analogue Scale for subjective pain assessment. The study was continued for 15 days or until the mucositis progressed to grade 3 or resolved to grade 1.

RESULT:

There was a significant reduction in the mean pain score and mean area of mucositis in the intervention group compared to the control group.

CONCLUSION:

Jati oral gel is a suitable medicament as an add-on therapy in managing grade 2 radiation-induced oral mucositis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Ayurveda Integr Med Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Ayurveda Integr Med Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos