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Association between brominated flame retardants (PBDEs and PBB153) exposure and hypertension in U.S. adults: results from NHANES 2005-2016.
Cheng, Dian; Chen, Zijun; Zhou, Jian; Cao, Yue; Xie, Xin; Wu, Yizhang; Li, Xiaorong; Wang, Xuecheng; Yu, Jinbo; Yang, Bing.
Afiliación
  • Cheng D; Department of Cardiovascular Medicine, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, Shanghai, 200120, P.R. China.
  • Chen Z; Department of Cardiovascular Medicine, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, Shanghai, 200120, P.R. China.
  • Zhou J; Department of Cardiovascular Medicine, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, Shanghai, 200120, P.R. China.
  • Cao Y; School of Resources and Environmental Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, P.R. China.
  • Xie X; Department of Cardiovascular Medicine, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, Shanghai, 200120, P.R. China.
  • Wu Y; Department of Cardiovascular Medicine, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, Shanghai, 200120, P.R. China.
  • Li X; Department of Cardiovascular Medicine, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, Shanghai, 200120, P.R. China.
  • Wang X; Department of Cardiovascular Medicine, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, Shanghai, 200120, P.R. China. wong_pump@163.com.
  • Yu J; Department of Cardiovascular Medicine, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, Shanghai, 200120, P.R. China. dryujinbo@126.com.
  • Yang B; Department of Cardiovascular Medicine, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, Shanghai, 200120, P.R. China.
Environ Health ; 23(1): 64, 2024 Jul 13.
Article en En | MEDLINE | ID: mdl-39003460
ABSTRACT

BACKGROUND:

Brominated Flame Retardants (BFRs) have attracted widespread concern due to their environmental persistence and potential toxicity. This study aims to examine the association between BFRs exposure and hypertension.

METHODS:

We used data from the National Health and Nutrition Examination Survey (NHANES) spanning 2005 to 2016 for the cross-sectional analysis. To evaluate the individual and combined impacts of BFRs exposure on hypertension, we utilized multivariate models, including generalized additive models, weighted quantile sum (WQS) regression, and Bayesian kernel machine regression (BKMR) models.

RESULTS:

9882 individuals (48% male) aged ≥ 20 were included in the final analysis, of whom 4114 had hypertension. After controlling for potential covariates, higher serum concentrations of PBDE100 (OR 1.26; 95% CI 1.01, 1.57) and PBDE153 (OR 1.50; 95% CI 1.18, 1.88) were significantly associated with hypertension. A nonlinear relationship between PBDE28 and hypertension was observed (P = 0.03). Moreover, BFRs mixture were positively associated with the prevalence of hypertension in both the WQS (ß1.09; 95% CI 1.02, 1.17; P = 0.02) and BKMR models.

CONCLUSION:

Our study suggested that BFRs exposure is positively associated with hypertension in the general population. To confirm this association and elucidate the mechanisms, further research is required.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encuestas Nutricionales / Exposición a Riesgos Ambientales / Contaminantes Ambientales / Éteres Difenilos Halogenados / Retardadores de Llama / Hipertensión Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Environ Health Asunto de la revista: SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encuestas Nutricionales / Exposición a Riesgos Ambientales / Contaminantes Ambientales / Éteres Difenilos Halogenados / Retardadores de Llama / Hipertensión Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Environ Health Asunto de la revista: SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido