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Chronic pain in multiple sites is associated with cardiovascular dysfunction: an observational UK Biobank cohort study.
Tian, Jing; Shen, Ziyuan; Sutherland, Brad A; Cicuttini, Flavia; Jones, Graeme; Pan, Feng.
Afiliación
  • Tian J; Cardiovascular Research Flagship, Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.
  • Shen Z; Musculoskeletal Health and Disease Theme, Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia; Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, AN, China.
  • Sutherland BA; Tasmanian School of Medicine, University of Tasmania, Hobart, TAS, Australia.
  • Cicuttini F; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
  • Jones G; Musculoskeletal Health and Disease Theme, Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.
  • Pan F; Musculoskeletal Health and Disease Theme, Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia. Electronic address: Feng.Pan@utas.edu.au.
Br J Anaesth ; 133(3): 605-614, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39003202
ABSTRACT

BACKGROUND:

Chronic pain is associated with development of cardiovascular disease. We investigated the association between how widespread chronic pain is and the development of cardiovascular dysfunction.

METHODS:

We analysed data from participants enrolled in the UK Biobank study who underwent examinations at baseline, plus first follow-up and two imaging visits. Pain sites (including hip, knee, back, neck/shoulder, or 'all over the body') and pain duration were recorded at each visit. Chronic pain was defined as pain lasting for ≥3 months. Participants were categorised into six groups no chronic pain, chronic pain in one, two, three, or four sites, or 'all over the body'. Arterial stiffness index was measured at each time point. Carotid intima-media thickness, cardiac index, and left ventricular ejection fraction (LVEF) were measured using ultrasound and heart MRI at two additional imaging visits in a subset of participants. Mixed-effect linear regression models were used for the analyses.

RESULTS:

The number of chronic pain sites was directly related to increased arterial stiffness index (n=159,360; ß=0.06 per one site increase, 95% confidence interval 0.04 to 0.08). In 23,899 participants, lower LVEF was associated with widespread chronic pain (ß=-0.17 per one site increase, 95% confidence interval -0.27 to -0.07). The number of chronic pain sites was not associated with carotid intima-media thickness (n=30,628) or cardiac index (n=23,899).

CONCLUSION:

A greater number of chronic pain sites is associated with increased arterial stiffness and poorer cardiac function, suggesting that widespread chronic pain is an important contributor to cardiovascular dysfunction.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Dolor Crónico Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Br J Anaesth Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Dolor Crónico Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Br J Anaesth Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido