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Innovating Leishmaniasis Treatment: A Critical Chemist's Review of Inorganic Nanomaterials.
Bessa, Isabela A A; D'Amato, Dayenny L; C Souza, Ana Beatriz; Levita, Daniel P; Mello, Camille C; da Silva, Aline F M; Dos Santos, Thiago C; Ronconi, Célia M.
Afiliación
  • Bessa IAA; Departamento de Química Inorgânica, Universidade Federal Fluminense, Campus do Valonguinho, Niterói, RJ 24020-150, Brazil.
  • D'Amato DL; Departamento de Química Inorgânica, Universidade Federal Fluminense, Campus do Valonguinho, Niterói, RJ 24020-150, Brazil.
  • C Souza AB; Departamento de Química Inorgânica, Universidade Federal Fluminense, Campus do Valonguinho, Niterói, RJ 24020-150, Brazil.
  • Levita DP; Departamento de Química Inorgânica, Universidade Federal Fluminense, Campus do Valonguinho, Niterói, RJ 24020-150, Brazil.
  • Mello CC; Departamento de Química Inorgânica, Universidade Federal Fluminense, Campus do Valonguinho, Niterói, RJ 24020-150, Brazil.
  • da Silva AFM; Departamento de Química Inorgânica, Universidade Federal Fluminense, Campus do Valonguinho, Niterói, RJ 24020-150, Brazil.
  • Dos Santos TC; Instituto de Química, Universidade Federal do Rio de Janeiro. Av. Athos da Silveira Ramos 149, CT, Cidade Universitária, Rio de Janeiro, RJ 21941-909, Brazil.
  • Ronconi CM; Departamento de Química Inorgânica, Universidade Federal Fluminense, Campus do Valonguinho, Niterói, RJ 24020-150, Brazil.
ACS Infect Dis ; 10(8): 2485-2506, 2024 Aug 09.
Article en En | MEDLINE | ID: mdl-39001837
ABSTRACT
Leishmaniasis, a critical Neglected Tropical Disease caused by Leishmania protozoa, represents a significant global health risk, particularly in resource-limited regions. Conventional treatments are effective but suffer from serious limitations, such as toxicity, prolonged treatment courses, and rising drug resistance. Herein, we highlight the potential of inorganic nanomaterials as an innovative approach to enhance Leishmaniasis therapy, aligning with the One Health concept by considering these treatments' environmental, veterinary, and public health impacts. By leveraging the adjustable properties of these nanomaterials─including size, shape, and surface charge, tailored treatments for various diseases can be developed that are less harmful to the environment and nontarget species. We review recent advances in metal-, oxide-, and carbon-based nanomaterials for combating Leishmaniasis, examining their mechanisms of action and their dual use as standalone treatments or drug delivery systems. Our analysis highlights a promising yet underexplored frontier in employing these materials for more holistic and effective disease management.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leishmaniasis / Nanoestructuras / Leishmania / Antiprotozoarios Límite: Animals / Humans Idioma: En Revista: ACS Infect Dis Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leishmaniasis / Nanoestructuras / Leishmania / Antiprotozoarios Límite: Animals / Humans Idioma: En Revista: ACS Infect Dis Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos