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Trends in primary care blood tests prior to lung and colorectal cancer diagnosis-A retrospective cohort study using linked Australian data.
Rafiq, Meena; Drosdowsky, Allison; Solomon, Ben; Alexander, Marliese; Gibbs, Peter; Wright, Gavin; Yeung, Justin M; Lyratzopoulos, Georgios; Emery, Jon.
Afiliación
  • Rafiq M; Department of General Practice and Centre for Cancer Research, University of Melbourne, Melbourne, Victoria, Australia.
  • Drosdowsky A; Epidemiology of Cancer Healthcare & Outcomes (ECHO) Group, Department of Behavioural Science and Health, Institute of Epidemiology and Health Care (IECH), UCL, London, UK.
  • Solomon B; Department of General Practice and Centre for Cancer Research, University of Melbourne, Melbourne, Victoria, Australia.
  • Alexander M; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
  • Gibbs P; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
  • Wright G; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
  • Yeung JM; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
  • Lyratzopoulos G; Department of Surgery, Western Precinct, University of Melbourne, Melbourne, Victoria, Australia.
  • Emery J; Epidemiology of Cancer Healthcare & Outcomes (ECHO) Group, Department of Behavioural Science and Health, Institute of Epidemiology and Health Care (IECH), UCL, London, UK.
Cancer Med ; 13(14): e70006, 2024 Jul.
Article en En | MEDLINE | ID: mdl-39001673
ABSTRACT

INTRODUCTION:

Abnormal results in common blood tests may occur several months before lung cancer (LC) and colorectal cancer (CRC) diagnosis. Identifying early blood markers of cancer and distinct blood test signatures could support earlier diagnosis in general practice.

METHODS:

Using linked Australian primary care and hospital cancer registry data, we conducted a cohort study of 855 LC and 399 CRC patients diagnosed between 2001 and 2021. Requests and results from general practice blood tests (six acute phase reactants [APR] and six red blood cell indices [RBCI]) were examined in the 2 years before cancer diagnosis. Poisson regression models were used to estimate monthly incidence rates and examine pre-diagnostic trends in blood test use and abnormal results prior to cancer diagnosis, comparing patterns in LC and CRC patients.

RESULTS:

General practice blood test requests increase from 7 months before CRC and 6 months before LC diagnosis. Abnormalities in many APR and RBCI tests increase several months before cancer diagnosis, often occur prior to or in the absence of anaemia (in 51% of CRC and 81% of LC patients with abnormalities), and are different in LC and CRC patients.

CONCLUSIONS:

This study demonstrates an increase in diagnostic activity in Australian general practice several months before LC and CRC diagnosis, indicating potential opportunities for earlier diagnosis. It identifies blood test abnormalities and distinct signatures that are early markers of LC and CRC. If combined with other pre-diagnostic information, these blood tests have potential to support GPs in prioritising patients for cancer investigation of different sites to expedite diagnosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Atención Primaria de Salud / Neoplasias Colorrectales / Pruebas Hematológicas / Neoplasias Pulmonares Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Oceania Idioma: En Revista: Cancer Med Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Atención Primaria de Salud / Neoplasias Colorrectales / Pruebas Hematológicas / Neoplasias Pulmonares Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Oceania Idioma: En Revista: Cancer Med Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos