Your browser doesn't support javascript.
loading
The Prospective Association between Early Life Growth and Breast Density in Young Adult Women.
Lloyd, Rachel; Pirikahu, Sarah; Walter, Jane; Cadby, Gemma; Warrington, Nicole; Perera, Dilukshi; Hickey, Martha; Saunders, Christobel; Hackmann, Michael; Sampson, David D; Shepherd, John; Lilge, Lothar; Stone, Jennifer.
Afiliación
  • Lloyd R; Genetic Epidemiology Group, School of Population and Global Health, The University of Western Australia, Perth, WA 6009, Australia.
  • Pirikahu S; Genetic Epidemiology Group, School of Population and Global Health, The University of Western Australia, Perth, WA 6009, Australia.
  • Walter J; University Health Network, Toronto, ON M5G 2C4, Canada.
  • Cadby G; Genetic Epidemiology Group, School of Population and Global Health, The University of Western Australia, Perth, WA 6009, Australia.
  • Warrington N; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4067, Australia.
  • Perera D; The Frazer Institute, The University of Queensland, Woolloongabba, QLD 4102, Australia.
  • Hickey M; Department of Public Health and Nursing, K.G. Jebsen Center for Genetic Epidemiology, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway.
  • Saunders C; Genetic Epidemiology Group, School of Population and Global Health, The University of Western Australia, Perth, WA 6009, Australia.
  • Hackmann M; Department of Obstetrics and Gynaecology, University of Melbourne and the Royal Women's Hospital, Melbourne, VIC 3052, Australia.
  • Sampson DD; Department of Surgery, The University of Melbourne, Parkville, VIC 3052, Australia.
  • Shepherd J; School of Human Sciences, The University of Western Australia, Crawley, WA 6009, Australia.
  • Lilge L; School of Computer Science and Electronic Engineering, The University of Surrey, Guildford, Surrey GU2 7XH, UK.
  • Stone J; Epidemiology and Population Sciences in the Pacific Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Cancers (Basel) ; 16(13)2024 Jun 30.
Article en En | MEDLINE | ID: mdl-39001479
ABSTRACT
Breast density is a strong intermediate endpoint to investigate the association between early-life exposures and breast cancer risk. This study investigates the association between early-life growth and breast density in young adult women measured using Optical Breast Spectroscopy (OBS) and Dual X-ray Absorptiometry (DXA). OBS measurements were obtained for 536 female Raine Cohort Study participants at ages 27-28, with 268 completing DXA measurements. Participants with three or more height and weight measurements from ages 8 to 22 were used to generate linear growth curves for height, weight and body mass index (BMI) using SITAR modelling. Three growth parameters (size, velocity and timing) were examined for association with breast density measures, adjusting for potential confounders. Women who reached their peak height rapidly (velocity) and later in adolescence (timing) had lower OBS-breast density. Overall, women who were taller (size) had higher OBS-breast density. For weight, women who grew quickly (velocity) and later in adolescence (timing) had higher absolute DXA-breast density. Overall, weight (size) was also inversely associated with absolute DXA-breast density, as was BMI. These findings provide new evidence that adolescent growth is associated with breast density measures in young adult women, suggesting potential mediation pathways for breast cancer risk in later life.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Suiza