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The Impact of Local Control on Overall Survival after Y-90 Selective Internal Radiotherapy of Liver Metastases in Oligometastatic Cancer: A Retrospective Analysis.
Yeakel, John; Seyedin, Steven N; Harada, Garrett; Hagopian, Garo; Mahmood, Sharmeen; Bennett, Rebecca; Harris, Jeremy P; Abbott, Elliot M; Lindner, Sydney; Dayyani, Farshid; Sehgal, Varun; Kuo, Jeffrey V; Abi-Jaoudeh, Nadine.
Afiliación
  • Yeakel J; Department of Radiation Oncology, University of California Irvine, Orange, CA 92868, USA.
  • Seyedin SN; Department of Radiation Oncology, Mayo Clinic, Rochester, MN 55902, USA.
  • Harada G; Department of Radiation Oncology, University of California Irvine, Orange, CA 92868, USA.
  • Hagopian G; Department of Radiation Oncology, University of California Irvine, Orange, CA 92868, USA.
  • Mahmood S; Department of Medicine, University of California Irvine, Orange, CA 92868, USA.
  • Bennett R; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA 92868, USA.
  • Harris JP; Division of Vascular and Interventional Radiology, Department of Radiological Sciences, University of California Irvine, Orange, CA 92868, USA.
  • Abbott EM; Department of Radiation Oncology, University of California Irvine, Orange, CA 92868, USA.
  • Lindner S; MIM Software Inc., Cleveland, OH 44122, USA.
  • Dayyani F; MIM Software Inc., Cleveland, OH 44122, USA.
  • Sehgal V; Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Orange, CA 92868, USA.
  • Kuo JV; Department of Radiation Oncology, University of California Irvine, Orange, CA 92868, USA.
  • Abi-Jaoudeh N; Department of Radiation Oncology, University of California Irvine, Orange, CA 92868, USA.
Cancers (Basel) ; 16(13)2024 Jun 29.
Article en En | MEDLINE | ID: mdl-39001464
ABSTRACT
Y-90 Selective Internal Radiotherapy (SIRT) is an ablative therapy used for inoperable liver metastasis. The purpose of this investigation was to examine the impact of local control after SIRT on overall survival (OS) in oligometastatic patients. A retrospective, single-institution study identified oligometastatic patients with ≤5 non-intracranial metastases receiving unilateral or bilateral lobar Y-90 SIRT from 2009 to 2021. The primary endpoint was OS defined from Y-90 SIRT completion to the date of death or last follow-up. Local failure was classified as a progressive disease at the target lesion(s) by RECIST v1.1 criteria starting at 3 months after SIRT. With a median follow-up of 15.7 months, 33 patients were identified who had a total of 79 oligometastatic lesions treated with SIRT, with the majority histology of colorectal adenocarcinoma (n = 22). In total, 94% of patients completed the Y-90 lobectomy. Of the 79 individual lesions treated, 22 (27.8%) failed. Thirteen patients received salvage liver-directed therapy following intrahepatic failure; ten received repeat SIRT. Median OS (mOS) was 20.1 months, and 12-month OS was 68.2%. Intralesional failure was associated with worse 1 y OS (52.3% vs. 86.2%, p = 0.004). These results suggest that intralesional failure following Y-90 may be associated with inferior OS, emphasizing the importance of disease control in low-metastatic-burden patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza