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Leisure-Time Physical Activity in Subjects with Metabolic-Dysfunction-Associated Steatotic Liver Disease: An All-Cause Mortality Study.
Curci, Ritanna; Bonfiglio, Caterina; Franco, Isabella; Bagnato, Claudia Beatrice; Verrelli, Nicola; Bianco, Antonella.
Afiliación
  • Curci R; Laboratory of Movement and Wellness, National Institute of Gastroenterology, IRCCS "S. de Bellis", Via Turi, 70013 Castellana Grotte, BA, Italy.
  • Bonfiglio C; Laboratory of Epidemiology and Statistics, National Institute of Gastroenterology, IRCCS "S. de Bellis", 70013 Castellana Grotte, BA, Italy.
  • Franco I; Laboratory of Movement and Wellness, National Institute of Gastroenterology, IRCCS "S. de Bellis", Via Turi, 70013 Castellana Grotte, BA, Italy.
  • Bagnato CB; Laboratory of Movement and Wellness, National Institute of Gastroenterology, IRCCS "S. de Bellis", Via Turi, 70013 Castellana Grotte, BA, Italy.
  • Verrelli N; Laboratory of Movement and Wellness, National Institute of Gastroenterology, IRCCS "S. de Bellis", Via Turi, 70013 Castellana Grotte, BA, Italy.
  • Bianco A; Laboratory of Movement and Wellness, National Institute of Gastroenterology, IRCCS "S. de Bellis", Via Turi, 70013 Castellana Grotte, BA, Italy.
J Clin Med ; 13(13)2024 Jun 27.
Article en En | MEDLINE | ID: mdl-38999337
ABSTRACT

Background:

Metabolic-dysfunction-associated steatotic liver disease (MASLD) affects 30% of adults worldwide and is associated with obesity and cardiovascular risk factors. If left untreated, it can progress to severe liver disease. Lifestyle changes such as physical activity and weight loss help to reduce the severity and risk of mortality. This study estimated the impact of MASLD and leisure-time physical activity (LTPA) on mortality and examined how gender mediates this effect in a Southern Italian population.

Methods:

This work is a population-based prospective cohort study of inhabitants of Castellana Grotte (>30 years old) in Southern Italy, which began in 1985. Participants provided general health information, underwent anthropometric measurements and ultrasonography, and completed a validated questionnaire on their food intake and LTPA. The vital status was tracked through local municipalities

Results:

In total, 1826 participants (39% with MASLD) were enrolled in this study, drawn from 2970 eligible subjects; the mean age was 51.91 (±14.76) years and 56.2% were men. Subjects with MASLD who practiced low LTPA had a significantly higher risk of death than those who did not have MASLD and practiced high LTPA. In addition, subjects with MASLD who practiced low LTPA were about 19% less likely to survive to the age of 82 years. As regards gender, both men and women with MASLD and low LTPA showed a significant risk of death, but this was higher in women.

Conclusions:

The presence of MASLD, especially in women, increases the risk of death from all causes. LTPA plays a key role in the disease and reduces mortality in these individuals.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza