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Analysis of factors associated with mortality due to sepsis resulting from device-related infections.
Amarante, Ana Cristina Alba; Linck Junior, Arnildo; Ferrari, Rosângela Aparecida Pimenta; Lopes, Gilselena Kerbauy; Capobiango, Jaqueline Dario.
Afiliación
  • Amarante ACA; Programa de Posgrado en Fisiopatología Clínica y de Laboratorio, Departamento de Patología, Análisis Clínicos y Toxicológicos, Centro de Ciencias de la Salud, Universidad Estatal de Londrina, Londrina-Paraná, Brazil.
  • Linck Junior A; Departamento de Pediatría y Cirugía Pediátrica, Centro de Ciencias de la Salud, Universidad Estatal de Londrina, Londrina-Paraná, Brazil.
  • Ferrari RAP; Departamento de Enfermería, Centro de Ciencias de la Salud, Universidad Estatal de Londrina, Londrina-Paraná, Brazil.
  • Lopes GK; Departamento de Enfermería, Centro de Ciencias de la Salud, Universidad Estatal de Londrina, Londrina-Paraná, Brazil.
  • Capobiango JD; Departamento de Pediatría y Cirugía Pediátrica, Centro de Ciencias de la Salud, Universidad Estatal de Londrina, Londrina-Paraná, Brazil. Electronic address: jaquedc@uel.br.
An Pediatr (Engl Ed) ; 101(2): 115-123, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38997941
ABSTRACT

INTRODUCTION:

Health care-associated infections (HAIs) contribute to morbidity and mortality and to the dissemination of multidrug-resistant organisms. Children admitted to the intensive care unit undergo invasive procedures that increase their risk of developing HAIs and sepsis. The aim of the study was to analyse factors associated with mortality due to sepsis arising from HAIs. PATIENTS AND

METHODS:

We conducted a case-control study in a 7-bed multipurpose paediatric intensive care unit in a tertiary care teaching hospital. The sample consisted of 90 children admitted between January 2014 and December 2018. The case group consisted of patients who died from sepsis associated with the main health care-associated infections; the control group consisted of patients who survived sepsis associated with the same infections.

RESULTS:

Death was associated with age less than or equal to 12 months, presence of comorbidity, congenital disease, recurrent ventilator-associated pneumonia and septic shock. In the multiple regression analysis, heart disease (OR, 12.48; CI 2.55-60.93; P = .002), infection by carbapenem-resistant bacteria (OR, 31.51; CI 4.01-247.25; P = .001), cancer (OR, 58.23; CI 4.54-746.27; P = .002), and treatment with adrenaline (OR, 13.14; CI 1.35-128.02; P = .003) continued to be significantly associated with death.

CONCLUSIONS:

Hospital sepsis secondary to carbapenem-resistant bacteria contributed to a high mortality rate in this cohort. Children with heart disease or neoplasia or who needed vasopressor drugs had poorer outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Unidades de Cuidado Intensivo Pediátrico / Infección Hospitalaria / Sepsis Límite: Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: An Pediatr (Engl Ed) Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: España
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Unidades de Cuidado Intensivo Pediátrico / Infección Hospitalaria / Sepsis Límite: Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: An Pediatr (Engl Ed) Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: España