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Early appearance of thyroid autoimmunity in children followed from birth for type 1 diabetes risk.
Jonsdottir, Berglind; Clasen, Joanna L; Vehik, Kendra; Lernmark, Åke; Lundgren, Markus; Bonifacio, Ezio; Schatz, Desmond; Ziegler, Anette-Gabriele; Hagopian, William; Rewers, Marian; McIndoe, Richard; Toppari, Jorma; Krischer, Jeffrey; Akolkar, Beena; Steck, Andrea; Veijola, Riitta; Haller, Michael J; Elding Larsson, Helena.
Afiliación
  • Jonsdottir B; The Children's Hospital Iceland, Reykjavik, Iceland.
  • Clasen JL; Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.
  • Vehik K; Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
  • Lernmark Å; Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
  • Lundgren M; Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.
  • Bonifacio E; Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.
  • Schatz D; Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.
  • Ziegler AG; Department of Pediatrics, University of Florida, Gainesville, FL, USA.
  • Hagopian W; Institute of Diabetes Research, Helmholtz Zentrum München, and Klinikum rechts der Isar, Technische Universität München, and Forschergruppe Diabetes e.V., Neuherberg, Germany.
  • Rewers M; Pacific Northwest Research Institute, Seattle WA, USA.
  • McIndoe R; Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO, USA.
  • Toppari J; Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
  • Krischer J; Department of Pediatrics, Turku University Hospital, Turku, Finland.
  • Akolkar B; Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology and Centre for Population Health Research, University of Turku, Turku, Finland.
  • Steck A; Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
  • Veijola R; National Institutes of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
  • Haller MJ; Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO, USA.
  • Elding Larsson H; Department of Pediatrics, Research Unit of Clinical Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
J Clin Endocrinol Metab ; 2024 Jul 12.
Article en En | MEDLINE | ID: mdl-38996042
ABSTRACT

PURPOSE:

Autoantibodies to thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) define pre-clinical autoimmune thyroid disease (AITD) which can progress to either clinical hypo- or hyperthyroidism. We determined the age at seroconversion in children genetically at risk for type 1 diabetes.

METHODS:

TPOAb and TgAb seropositivity were determined in 5066 healthy children with HLA DR3 or DR4 containing haplogenotypes from The Environmental Determinants of Diabetes in the Young (TEDDY) Study. Children seropositive on the cross-sectional initial screen at 8-13 years of age had longitudinally collected samples (from 3.5 months of age) screened retrospectively and prospectively for thyroid autoantibodies to identify the age at seroconversion. First-appearing autoantibody was related to sex, HLA genotype, family history of AITD, and subsequent thyroid dysfunction and disease.

RESULTS:

The youngest appearance of TPOAb and TgAb was 10 and 15 months of age, respectively. Girls had higher incidence rates of both autoantibodies. Family history of AITD was associated with a higher risk of TPOAb hazard ratio [HR] 1.90, 95% confidence interval [CI] 1.17, 3.08; and TgAb HR 2.55, 95% CI 1.91, 3.41. The risk of progressing to hypo- or hyperthyroidism was not different between TgAb and TPOAb, but children with both autoantibodies appearing at the same visit had a higher risk compared to TPOAb appearing first (HR 6.34, 95% CI 2.72, 14.76). MAIN

CONCLUSION:

Thyroid autoantibodies may appear during the first years of life, especially in girls, and in children with a family history of AITD. Simultaneous appearance of both autoantibodies increases the risk for hypo- or hyperthyroidism.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Endocrinol Metab Año: 2024 Tipo del documento: Article País de afiliación: Islandia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Endocrinol Metab Año: 2024 Tipo del documento: Article País de afiliación: Islandia Pais de publicación: Estados Unidos