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Long-lived enhanced magnetization-A practical metabolic MRI contrast material.
Katz, Itai; Schmidt, Asher; Ben-Shir, Ira; Javitt, Marcia; Kouril, Karel; Capozzi, Andrea; Meier, Benno; Lang, Arad; Pokroy, Boaz; Blank, Aharon.
Afiliación
  • Katz I; Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
  • Schmidt A; Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
  • Ben-Shir I; Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
  • Javitt M; Rambam Medical Center, Haifa, Israel.
  • Kouril K; Institute of Biological Interfaces 4, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen 76344, Germany.
  • Capozzi A; LIFMET, Institute of Physics, École Polytechnique Fédérale de Lausanne (EPFL), Station 6, 1015 Lausanne, Switzerland.
  • Meier B; HYPERMAG, Department of Health Technology, Technical University of Denmark, Building 349, 2800 Kgs Lyngby, Denmark.
  • Lang A; Institute of Biological Interfaces 4, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen 76344, Germany.
  • Pokroy B; Institute of Physical Chemistry, Karlsruhe Institute of Technology, Karlsruhe 76131, Germany.
  • Blank A; Department of Materials Science and Engineering, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
Sci Adv ; 10(28): eado2483, 2024 Jul 12.
Article en En | MEDLINE | ID: mdl-38996017
ABSTRACT
Noninvasive tracking of biochemical processes in the body is paramount in diagnostic medicine. Among the leading techniques is spectroscopic magnetic resonance imaging (MRI), which tracks metabolites with an amplified (hyperpolarized) magnetization signal injected into the subject just before scanning. Traditionally, the brief enhanced magnetization period of these agents limited clinical imaging. We propose a solution based on amalgamating two materials-one having diagnostic-metabolic activity and the other characterized by robust magnetization retention. This combination slows the magnetization decay in the diagnostic metabolic probe, which receives continuously replenished magnetization from the companion material. Thus, it extends the magnetization lifetime in some of our measurements to beyond 4 min, with net magnetization enhanced by more than four orders of magnitude. This could allow the metabolic probes to remain magnetized from injection until they reach the targeted organ, improving tissue signatures in clinical imaging. Upon validation, this metabolic MRI technique promises wide-ranging clinical applications, including diagnostic imaging, therapeutic monitoring, and posttreatment surveillance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Medios de Contraste Límite: Animals / Humans Idioma: En Revista: Sci Adv Año: 2024 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Medios de Contraste Límite: Animals / Humans Idioma: En Revista: Sci Adv Año: 2024 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos