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Biological functions and potential mechanisms of miR­143­3p in cancers (Review).
Wu, Jia; Zhu, Ying; Liu, Dandan; Cong, Qingwei; Bai, Changchuan.
Afiliación
  • Wu J; Department of Infectious Diseases, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116000, P.R. China.
  • Zhu Y; Department of Infectious Diseases, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116000, P.R. China.
  • Liu D; Department of Infectious Diseases, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116000, P.R. China.
  • Cong Q; Department of Infectious Diseases, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116000, P.R. China.
  • Bai C; Dalian Hospital of Traditional Chinese Medicine, Dalian, Liaoning 116013, P.R. China.
Oncol Rep ; 52(3)2024 Sep.
Article en En | MEDLINE | ID: mdl-38994765
ABSTRACT
In recent years, microRNAs (miRNAs or miRs) have been increasingly studied for their role in cancer and have shown potential as cancer biomarkers. miR­143­3p and miR­143­5p are the mature miRNAs derived from pre­miRNA­143. At present, there are numerous studies on the function of miR­143­3p in cancer progression, but there are no systematic reviews describing the function of miR­143­3p in cancer. It is widely considered that miR­143­3p is downregulated in most malignant tumors and that upstream regulators can act on this gene, which in turn regulates the corresponding target to act on the tumor. In addition, miRNA­143­3p can regulate target genes to affect the biological process of tumors through various signaling pathways, such as the PI3K/Akt, Wnt/ß­catenin, AKT/STAT3 and Ras­Raf­MEK­ERK pathways. The present review comprehensively described the biogenesis of miR­143­3p, the biological functions of miR­143­3p and the related roles and mechanisms in different cancer types. The potential of miR­143­3p as a biomarker for cancer was also highlighted and valuable future research directions were discussed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Regulación Neoplásica de la Expresión Génica / MicroARNs / Neoplasias Límite: Humans Idioma: En Revista: Oncol Rep Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article Pais de publicación: Grecia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Regulación Neoplásica de la Expresión Génica / MicroARNs / Neoplasias Límite: Humans Idioma: En Revista: Oncol Rep Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article Pais de publicación: Grecia