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Metal-detection based techniques and their applications in metallobiology.
Zhou, Ying; Li, Hongyan; Tse, Eric; Sun, Hongzhe.
Afiliación
  • Zhou Y; Department of Chemistry, CAS-HKU Joint Laboratory of Metallomics for Health and Environment, The University of Hong Kong Pokfulam Road Hong Kong SAR P. R. China zy2014@connect.hku.hk hylichem@hku.hk hsun@hku.hk.
  • Li H; Department of Chemistry, CAS-HKU Joint Laboratory of Metallomics for Health and Environment, The University of Hong Kong Pokfulam Road Hong Kong SAR P. R. China zy2014@connect.hku.hk hylichem@hku.hk hsun@hku.hk.
  • Tse E; Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong Pokfulam Road Hong Kong SAR P. R. China ewctse@hku.hk.
  • Sun H; Department of Chemistry, CAS-HKU Joint Laboratory of Metallomics for Health and Environment, The University of Hong Kong Pokfulam Road Hong Kong SAR P. R. China zy2014@connect.hku.hk hylichem@hku.hk hsun@hku.hk.
Chem Sci ; 15(27): 10264-10280, 2024 Jul 10.
Article en En | MEDLINE | ID: mdl-38994399
ABSTRACT
Metals are essential for human health and play a crucial role in numerous biological processes and pathways. Gaining a deeper insight into these biological events will facilitate novel strategies for disease prevention, early detection, and personalized treatment. In recent years, there has been significant progress in the development of metal-detection based techniques from single cell metallome and proteome profiling to multiplex imaging, which greatly enhance our comprehension of the intricate roles played by metals in complex biological systems. This perspective summarizes the recent progress in advanced metal-detection based techniques and highlights successful applications in elucidating the roles of metals in biology and medicine. Technologies including machine learning that couple with single-cell analysis such as mass cytometry and their application in metallobiology, cancer biology and immunology are also emphasized. Finally, we provide insights into future prospects and challenges involved in metal-detection based techniques, with the aim of inspiring further methodological advancements and applications that are accessible to chemists, biologists, and clinicians.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Sci Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Sci Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido