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Socioeconomic traits and the risk of Barrett's esophagus and gastroesophageal reflux disease: A Mendelian randomization study.
Liu, Yu-Xin; Bin, Cheng-Li; Zhang, Lu; Yang, Wen-Tao; An, Bai-Ping.
Afiliación
  • Liu YX; Department of Oncology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China.
  • Bin CL; Department of Gynecology and Obstetrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China.
  • Zhang L; Department of Endocrine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China.
  • Yang WT; Department of Cardiovascular, Chengdu Integrated TCM & Western Medicine Hospital, Chengdu 610041, Sichuan Province, China.
  • An BP; Department of Oncology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China. anbaiping@cdutcm.edu.cn.
World J Gastrointest Oncol ; 16(6): 2631-2645, 2024 Jun 15.
Article en En | MEDLINE | ID: mdl-38994145
ABSTRACT

BACKGROUND:

Previous observational studies have shown that the prevalence of gastroesophageal reflux disease (GERD) and Barrett's esophagus (BE) is associated with socioeconomic status. However, due to the methodological limitations of traditional observational studies, it is challenging to definitively establish causality.

AIM:

To explore the causal relationship between the prevalence of these conditions and socioeconomic status using Mendelian randomization (MR).

METHODS:

We initially screened single nucleotide polymorphisms (SNPs) to serve as proxies for eight socioeconomic status phenotypes for univariate MR analysis. The inverse variance weighted (IVW) method was used as the primary analytical method to estimate the causal relationship between the eight socioeconomic status phenotypes and the risk of GERD and BE. We then collected combinations of SNPs as composite proxies for the eight socioeconomic phenotypes to perform multivariate MR (MVMR) analyses based on the IVW MVMR model. Furthermore, a two-step MR mediation analysis was used to examine the potential mediation of the associations by body mass index, major depressive disorder (MDD), smoking, alcohol consumption, and sleep duration.

RESULTS:

The study identified three socioeconomic statuses that had a significant impact on GERD. These included household income [odds ratio (OR) 0.46; 95% confidence interval (95%CI) 0.31-0.70], education attainment (OR 0.23; 95%CI 0.18-0.29), and the Townsend Deprivation Index at recruitment (OR 1.57; 95%CI 1.04-2.37). These factors were found to independently and predominantly influence the genetic causal effect of GERD. Furthermore, the mediating effect of educational attainment on GERD was found to be mediated by MDD (proportion mediated 10.83%). Similarly, the effect of educational attainment on BE was mediated by MDD (proportion mediated 10.58%) and the number of cigarettes smoked per day (proportion mediated 3.50%). Additionally, the mediating effect of household income on GERD was observed to be mediated by sleep duration (proportion mediated 9.75%).

CONCLUSION:

This MR study shed light on the link between socioeconomic status and GERD or BE, providing insights for the prevention of esophageal cancer and precancerous lesions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: World J Gastrointest Oncol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: World J Gastrointest Oncol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China