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Intravenous Lidocaine for the Management of Chronic Pain: A Narrative Review of Randomized Clinical Trials.
Onyeaka, Henry; Adeola, Janet; Xu, Rebecca; Pappy, Adlai Liburne; Adeola, Sarah; Smucker, Marchelle; Chang, Albert; Fraga, Anthony; Ufondu, Wisdom; Osman, Moyasar; Hasoon, Jamal; Orhurhu, Vwaire J.
Afiliación
  • Onyeaka H; Onyeaka, Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; Department of Psychiatry, Mclean Hospital, Belmont, MA, USA.
  • Adeola J; Janet Adeola, Department of Anesthesiology and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Xu R; Xu, Department of Anesthesiology and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Pappy AL; Pappy, Department of Anesthesiology and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Adeola S; Sarah Adeola, Howard University, Washington, USA.
  • Smucker M; Smucker, Edward Via College of Osteopathic Medicine, USA.
  • Chang A; Chang, Department of Physical Medicine and Rehabilitation, University of Washington, USA.
  • Fraga A; Fraga, Department of Anesthesiology, Stanford University, California, USA.
  • Ufondu W; Ufondu, Department of Biology, Program in Liberal Medical Education (PLME), Brown University, Providence, RI, USA.
  • Osman M; Osman, Department of Psychology, New York University, New York, NY, USA.
  • Hasoon J; Hasoon, Department of Anesthesiology, University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Orhurhu VJ; Orhurhu, University of Pittsburgh Medical Center, Susquehanna, Williamsport, PA, USA; MVM Health, East Stroudsburg, PA, USA.
Psychopharmacol Bull ; 54(3): 73-96, 2024 Jul 08.
Article en En | MEDLINE | ID: mdl-38993659
ABSTRACT

Background:

Chronic pain remains a serious health problem with significant impact on morbidity and well-being. Available treatments have only resulted in relatively modest efficacy. Thus, novel therapeutic treatments with different mechanisms have recently generated empirical interest. Lidocaine is postulated to provide anti-inflammatory and anti-nociceptive effect through its action at the N-methyl-D-aspartate (NMDA) and voltage gated calcium receptors. Emerging research indicates that lidocaine could be a reasonable alternative for treating chronic pain.

Objective:

Considering the evidence surrounding lidocaine's potential as a therapeutic modality for chronic pain, we conducted a narrative review on the evidence of lidocaine's therapeutic effects in chronic pain.

Methods:

A review of the PubMed, and Google scholar databases was undertaken in May 2022 to identify completed studies that investigated the effectiveness of lidocaine in the treatment of chronic pain from database inception to June 2022.

Results:

A total of 25 studies were included in the narrative review. Findings on available studies suggest that intravenous infusion of lidocaine is an emerging and promising option that may alleviate pain in some clinical populations. Our narrative synthesis showed that evidence for intravenous lidocaine is currently mixed for a variety of chronic pain syndromes. Findings indicate that evidence for efficacy is limited for CRPS, and cancer pain. However, there is good evidence supporting the efficacy of intravenous lidocaine as augmentation in chronic post-surgical pain.

Conclusion:

Lidocaine may be a promising pharmacologic solution for chronic pain. Future investigation is warranted on elucidating the neurobiological mechanisms of lidocaine in attenuating pain signaling pathways.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ensayos Clínicos Controlados Aleatorios como Asunto / Dolor Crónico / Anestésicos Locales / Lidocaína Límite: Humans Idioma: En Revista: Psychopharmacol Bull Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ensayos Clínicos Controlados Aleatorios como Asunto / Dolor Crónico / Anestésicos Locales / Lidocaína Límite: Humans Idioma: En Revista: Psychopharmacol Bull Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos