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Protective effect of tert-butylhydroquinone against cisplatin-induced hepatorenal injury via modulating oxidative stress, inflammation, and apoptosis.
Ujah, Godwin Adakole; Ofutet, Emmanuel Oleba; Ukam, Catherine Ironya-Ogar; Omiunu, Precious Evangeline; Ackley, Emaediong Ufot; Japhet, Iboro Godwin; Ntauko, Jane Charles; Clement, Queen Comfort; Atu, Racheal; Nna, Victor Udo.
Afiliación
  • Ujah GA; Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Cross River State, Nigeria.
  • Ofutet EO; Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Cross River State, Nigeria.
  • Ukam CI; Department of Physiology, Faculty of Medicine and Pharmaceutical Science, Kampala International University, Tanzania.
  • Omiunu PE; Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Cross River State, Nigeria.
  • Ackley EU; Cellular Immunology, International Centre for Genetic Engineering and Biotechnology, ICGEB, Trieste, Italy.
  • Japhet IG; Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Cross River State, Nigeria.
  • Ntauko JC; Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Cross River State, Nigeria.
  • Clement QC; Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Cross River State, Nigeria.
  • Atu R; Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Cross River State, Nigeria.
  • Nna VU; Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Cross River State, Nigeria.
Arch Physiol Biochem ; : 1-11, 2024 Jul 11.
Article en En | MEDLINE | ID: mdl-38993034
ABSTRACT
CONTEXT Cisplastin (CDDP) is a chemotherapeutic drug frequently used to manage a variety of cancers. However, its use is associated with hepatorenal toxicity resulting from elevated reactive oxygen species production.

OBJECTIVE:

Herein, the hepatorenal protective effect of tert-butylhydroquinone (tBHQ) in cisplatin (CDDP)-treated rats was examined.

METHODS:

Wistar male rats randomly divided into four groups normal control, tBHQ, CDDP and tBHQ + CDDP received 50 mg/kg b.w./day of tBHQ orally for 14 days while 7 mg/kg b.w of CDDP was administered intraperitoneally on Day 8.

RESULTS:

CDDP increased serum biomarkers of hepatic (AST, ALP, ALT, GGT) and renal (creatinine, urea, uric acid, kidney injury molecule 1) function. The levels of nuclear factor erythroid-2-related factor 2 protein and the activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase activities were decreased in liver and kidney. Also, CDDP increased hepatic and renal levels of NF-κB, TNFα, Bax and caspase-3 proteins and decreased hepatorenal levels of Bcl-2 protein in the liver and kidney. Pre-treatment with tBHQ prevented these negative effects.

SIGNIFICANCE:

Pre-intervention with tBHQ attenuates hepatorenal toxicity of CDDP by dampening oxidative stress, inflammation and apoptosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Arch Physiol Biochem Asunto de la revista: BIOQUIMICA / FISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Nigeria Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Arch Physiol Biochem Asunto de la revista: BIOQUIMICA / FISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Nigeria Pais de publicación: Reino Unido