Breathe and bloom: Gut hypoxia limits C. albicans growth.

Mishra, Animesh A; Koh, Andrew Y

Mishra, Animesh A; Koh, Andrew Y.

Afiliación

Mishra AA; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Koh AY; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: andrew.koh@utsouthwestern.edu.

Cell Host Microbe ; 32(7): 1041-1043, 2024 Jul 10.

Article en En | MEDLINE | ID: mdl-38991499

ABSTRACT

ABSTRACT

Multiple host and microbial factors dictate whether Candida albicans can colonize the mammalian gastrointestinal tract. In this issue of Cell Host & Microbe, Savage et al. demonstrate that restoration of intestinal epithelial hypoxia is sufficient to restore Candida albicans colonization resistance, even when other Candida inhibitory effectors remain depleted.

Asunto(s)

Candida albicans; Candidiasis; Tracto Gastrointestinal; Candida albicans/crecimiento & desarrollo; Candida albicans/fisiología; Humanos; Tracto Gastrointestinal/microbiología; Candidiasis/microbiología; Animales; Hipoxia/metabolismo; Mucosa Intestinal/microbiología; Mucosa Intestinal/metabolismo; Ratones; Interacciones Huésped-Patógeno; Microbioma Gastrointestinal/fisiología

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candida albicans / Candidiasis / Tracto Gastrointestinal Límite: Animals / Humans Idioma: En Revista: Cell Host Microbe Asunto de la revista: MICROBIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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