Pioneer factors: Emerging rules of engagement for transcription factors on chromatinized DNA.

Carminati, Manuel; Vecchia, Luca; Stoos, Lisa; Thomä, Nicolas H

Carminati, Manuel; Vecchia, Luca; Stoos, Lisa; Thomä, Nicolas H.

Afiliación

Carminati M; Swiss Institute for Experimental Cancer Research (ISREC), EPFL, Lausanne 1015, Switzerland.
Vecchia L; Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel 4058, Switzerland.
Stoos L; Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel 4058, Switzerland.
Thomä NH; Swiss Institute for Experimental Cancer Research (ISREC), EPFL, Lausanne 1015, Switzerland; Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel 4058, Switzerland. Electronic address: Nicolas.thoma@epfl.ch.

Curr Opin Struct Biol ; 88: 102875, 2024 Oct.

Article en En | MEDLINE | ID: mdl-38991237

ABSTRACT

ABSTRACT

Pioneering transcription factors (TFs) can drive cell fate changes by binding their DNA motifs in a repressive chromatin environment. Recent structures illustrate emerging rules for nucleosome engagement TFs distort the nucleosomal DNA to gain access or employ alternative DNA-binding modes with smaller footprints, they preferentially access solvent-exposed motifs near the entry/exit sites, and frequently interact with histones. The extent of TF-histone interactions, in turn, depends on the motif location on the nucleosome, the type of DNA-binding fold, and adjacent domains present. TF-histone interactions can phase TF motifs relative to nucleosomes, and we discuss how these complex and surprisingly diverse interactions between nucleosomes and TFs contribute to function.

Asunto(s)

Cromatina; ADN; Nucleosomas; Factores de Transcripción; ADN/metabolismo; ADN/química; Factores de Transcripción/metabolismo; Factores de Transcripción/química; Cromatina/metabolismo; Cromatina/química; Nucleosomas/metabolismo; Nucleosomas/química; Humanos; Unión Proteica; Animales; Histonas/metabolismo; Histonas/química

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Transcripción / ADN / Cromatina / Nucleosomas Límite: Animals / Humans Idioma: En Revista: Curr Opin Struct Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido

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