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Incomplete resection of the intracranial electroencephalographic seizure onset zone is not associated with postsurgical outcomes.
Gascoigne, Sarah J; Evans, Nathan; Hall, Gerard; Kozma, Csaba; Panagiotopoulou, Mariella; Schroeder, Gabrielle M; Simpson, Callum; Thornton, Christopher; Turner, Frances; Woodhouse, Heather; Blickwedel, Jess; Chowdhury, Fahmida A; Diehl, Beate; Duncan, John S; Faulder, Ryan; Thomas, Rhys H; Wilson, Kevin; Taylor, Peter N; Wang, Yujiang.
Afiliación
  • Gascoigne SJ; Computational Neurology, Neuroscience & Psychiatry (CNNP) Lab, Interdisciplinary Computing and Complex BioSystems Group, School of Computing, Newcastle University, Newcastle Upon Tyne, UK.
  • Evans N; Computational Neurology, Neuroscience & Psychiatry (CNNP) Lab, Interdisciplinary Computing and Complex BioSystems Group, School of Computing, Newcastle University, Newcastle Upon Tyne, UK.
  • Hall G; Computational Neurology, Neuroscience & Psychiatry (CNNP) Lab, Interdisciplinary Computing and Complex BioSystems Group, School of Computing, Newcastle University, Newcastle Upon Tyne, UK.
  • Kozma C; Computational Neurology, Neuroscience & Psychiatry (CNNP) Lab, Interdisciplinary Computing and Complex BioSystems Group, School of Computing, Newcastle University, Newcastle Upon Tyne, UK.
  • Panagiotopoulou M; Computational Neurology, Neuroscience & Psychiatry (CNNP) Lab, Interdisciplinary Computing and Complex BioSystems Group, School of Computing, Newcastle University, Newcastle Upon Tyne, UK.
  • Schroeder GM; Computational Neurology, Neuroscience & Psychiatry (CNNP) Lab, Interdisciplinary Computing and Complex BioSystems Group, School of Computing, Newcastle University, Newcastle Upon Tyne, UK.
  • Simpson C; Computational Neurology, Neuroscience & Psychiatry (CNNP) Lab, Interdisciplinary Computing and Complex BioSystems Group, School of Computing, Newcastle University, Newcastle Upon Tyne, UK.
  • Thornton C; Computational Neurology, Neuroscience & Psychiatry (CNNP) Lab, Interdisciplinary Computing and Complex BioSystems Group, School of Computing, Newcastle University, Newcastle Upon Tyne, UK.
  • Turner F; Computational Neurology, Neuroscience & Psychiatry (CNNP) Lab, Interdisciplinary Computing and Complex BioSystems Group, School of Computing, Newcastle University, Newcastle Upon Tyne, UK.
  • Woodhouse H; Computational Neurology, Neuroscience & Psychiatry (CNNP) Lab, Interdisciplinary Computing and Complex BioSystems Group, School of Computing, Newcastle University, Newcastle Upon Tyne, UK.
  • Blickwedel J; Computational Neurology, Neuroscience & Psychiatry (CNNP) Lab, Interdisciplinary Computing and Complex BioSystems Group, School of Computing, Newcastle University, Newcastle Upon Tyne, UK.
  • Chowdhury FA; University College London Queen Square Institute of Neurology, Queen Square, London, UK.
  • Diehl B; University College London Queen Square Institute of Neurology, Queen Square, London, UK.
  • Duncan JS; University College London Queen Square Institute of Neurology, Queen Square, London, UK.
  • Faulder R; Computational Neurology, Neuroscience & Psychiatry (CNNP) Lab, Interdisciplinary Computing and Complex BioSystems Group, School of Computing, Newcastle University, Newcastle Upon Tyne, UK.
  • Thomas RH; Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK.
  • Wilson K; School of Mathematics, Statistics, and Physics, Newcastle University, Newcastle Upon Tyne, UK.
  • Taylor PN; Computational Neurology, Neuroscience & Psychiatry (CNNP) Lab, Interdisciplinary Computing and Complex BioSystems Group, School of Computing, Newcastle University, Newcastle Upon Tyne, UK.
  • Wang Y; University College London Queen Square Institute of Neurology, Queen Square, London, UK.
Epilepsia ; 65(9): e163-e169, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38990082
ABSTRACT
Delineation of seizure onset regions using intracranial electroencephalography (icEEG) is vital in the surgical workup of drug-resistant epilepsy cases. However, it is unknown whether the complete resection of these regions is necessary for seizure freedom, or whether postsurgical seizure recurrence can be attributed to the incomplete removal of seizure onset regions. To address this gap, we retrospectively analyzed icEEG recordings from 63 subjects, identifying seizure onset regions visually and algorithmically. We assessed onset region resection and correlated this with postsurgical seizure control. The majority of subjects had more than half of their onset regions resected (82.46% and 80.65% of subjects using visual and algorithmic methods, respectively). There was no association between the proportion of the seizure onset zone (SOZ) that was subsequently resected and better surgical outcomes (area under the receiver operating characteristic curve [AUC] < .7). Investigating the spatial extent of onset regions, we found no substantial evidence of an association with postsurgical seizure control (all AUC < .7). Although seizure onset regions are typically resected completely or in large part, incomplete resection is not associated with worse postsurgical outcomes. We conclude that postsurgical seizure recurrence cannot be attributed to an incomplete resection of the icEEG SOZ alone. Other network mechanisms beyond icEEG seizure onset likely contribute.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Convulsiones / Epilepsia Refractaria / Electrocorticografía Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Epilepsia Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Convulsiones / Epilepsia Refractaria / Electrocorticografía Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Epilepsia Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos